Stolarczyk Ania, Bawany Fatima, Hernandez Simon, Scott Glynis A, Cordisco Maria R
Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.
Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Dermatol Res Pract. 2023 Dec 9;2023:9267263. doi: 10.1155/2023/9267263. eCollection 2023.
Granuloma annulare (GA) is a common, benign, idiopathic inflammatory dermatosis. Aside from case reports and small studies, there are limited data about the characteristics of GA in children.
This study aimed to better characterize the epidemiologic and clinical features, triggering factors, disease associations, and outcomes of GA in the pediatric population.
We conducted a retrospective study of 73 pediatric patients diagnosed with GA at the University of Rochester Medical Center over a 7-year period.
The most common subtype was localized GA (71.2%, = 52), followed by subcutaneous (also known as "deep GA"; 16.4%, = 12) and generalized (12.3%, = 9) subtypes. Over 90% of patients had idiopathic GA, with the remaining patients reporting viral infection or trauma as triggers. Half of the patients studied had comorbid conditions, most frequently atopic dermatitis (17.8%, = 13), obesity (9.59%, = 7), asthma (6.85%, = 5), and allergic rhinitis (6.85%, = 5). The median duration of the disease was 11.00 months (interquartile range (IQR) 15.75 months); generalized GA had the shortest duration (median 10.00 months, IQR 15.50 months), while subcutaneous GA had the longest duration (median 12.00 months and IQR 29.00 months). Although recurrence rates for subcutaneous and generalized GA were high at 45.5% and 33.3%, respectively, most patients achieved clearance or improvement with treatment.
Most cases of GA in our study were idiopathic, with no clear differences between GA subtypes and associated comorbidities. Topical steroids were the most prescribed treatment with mixed efficacy.
环状肉芽肿（GA）是一种常见的、良性的、特发性炎症性皮肤病。除了病例报告和小型研究外，关于儿童GA特征的数据有限。
本研究旨在更好地描述儿童GA的流行病学和临床特征、触发因素、疾病关联及转归。
我们对罗切斯特大学医学中心7年间诊断为GA的73例儿科患者进行了一项回顾性研究。
最常见的亚型是局限性GA（71.2%，n = 52），其次是皮下型（也称为“深部GA”；16.4%，n = 12）和泛发型（12.3%，n = 9）。超过90%的患者为特发性GA，其余患者报告病毒感染或创伤为触发因素。半数研究患者有合并症，最常见的是特应性皮炎（17.8%，n = 13）、肥胖（9.59%，n = 7）、哮喘（6.85%，n = 5）和变应性鼻炎（6.85%，n = 5）。疾病的中位持续时间为11.00个月（四分位间距[IQR]15.75个月）；泛发型GA持续时间最短（中位10.00个月，IQR 15.50个月），而皮下型GA持续时间最长（中位12.00个月，IQR 29.00个月）。虽然皮下型和泛发型GA的复发率分别高达45.5%和33.3%，但大多数患者经治疗后病情得到缓解或改善。
我们研究中的大多数GA病例为特发性，GA各亚型与合并症之间无明显差异。外用糖皮质激素是最常用的治疗方法，疗效不一。
