Aksu Ayşe Esra Koku, Erdil Dilara İlhan, Baş Vildan Manav, Türk Cemre Büşra, Leblebici Cem, Tellal Ebru Sarıkaya
Health Sciences University, Istanbul Training and Research Hospital, Dermatology Clinic, Istanbul, Turkey.
Health Sciences University, Istanbul Training and Research Hospital, Clinic of Medical Pathology, Istanbul, Turkey.
Dermatol Pract Concept. 2023 Jan 1;13(1):e2023113. doi: 10.5826/dpc.1301a113.
Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited.
Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases.
This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded.
Forty-one participants were included in this study, of which 66% were females. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on 21 patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern.
Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis.
环状肉芽肿（GA）是一种可影响儿童和成人的非感染性肉芽肿性疾病。尽管针对成人GA患者已开展了许多研究，但有关儿童GA病例的文献有限。
因此，本研究旨在探讨儿童GA病例的人口统计学、临床和病理特征。
本研究在一家单中心三级皮肤病医院进行回顾性研究。记录人口统计学特征以及临床和组织病理学特征。
本研究纳入了41名参与者，其中66%为女性。平均年龄为3.8±2.6岁，平均病损持续时间为7.5±10.3个月。78%的患者病损为局限性，其余22%为泛发性。哮喘（30%）是最常见的合并疾病。对21名患者进行了组织病理学检查，71%的病例浸润模式为间质型，29%为栅栏状。间质型患者的泛发性分布、躯干受累及合并疾病发生率往往高于栅栏状患者。
对于儿童GA病例，应询问特应性和哮喘情况。受累、分布、合并疾病及组织病理学模式存在差异，这可能表明发病机制存在差异。
