Saini Prasanta, Fathima Pananchikkaparambil Abdu, Aiswarya Rema Suresh, Ajithlal Puthenpurackal Madhavan, Rajesh Koothupalakkal Ravi, Simi Surendran Maheswari, Pradeep Kumar Narendran, Kumar Ashwani
Indian Council of Medical Research-Vector Control Research Centre (Field Station), Kottayam, India.
Department of Infectious Disease, Government Medical College, Thrissur, India.
Am J Trop Med Hyg. 2023 Dec 18;110(1):59-63. doi: 10.4269/ajtmh.22-0586. Print 2024 Jan 3.
The tribal population in and around the Western Ghats region of India is affected by both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) with typical clinical symptoms. In this study, we recorded and analyzed seven CL and three VL cases from this emerging belt. All the cases were found as autochthonous transmission. Multiple genetic markers (minicircle kinetoplast DNA polymerase chain reaction and restriction fragment length polymorphism of 3'untranslated region heat shock protein (HSP) 70, a larger segment of HSP 70, and 6-phosphogluconate dehydrogenase [PGDH] gene sequences) were used to identify and characterize the parasite. It was found that both clinical manifestations are caused by zymodeme MON-37 of Leishmania donovani. We have investigated the detailed entomological and epidemiological aspects of disease transmission. An abundant population of the proven vector Phlebotomus argentipes was observed in the study villages.
印度西高止山脉地区及其周边的部落人口受到皮肤利什曼病（CL）和内脏利什曼病（VL）的影响，并伴有典型临床症状。在本研究中，我们记录并分析了来自这个新兴地区的7例CL病例和3例VL病例。所有病例均为本地传播。使用多种遗传标记（微小环动质体DNA聚合酶链反应以及3'非翻译区热休克蛋白（HSP）70、更大片段的HSP 70和6-磷酸葡萄糖酸脱氢酶[PGDH]基因序列的限制性片段长度多态性）来鉴定和表征寄生虫。结果发现，这两种临床表现均由杜氏利什曼原虫酶型MON-37引起。我们对疾病传播的详细昆虫学和流行病学方面进行了调查。在研究村庄中观察到了大量已证实的传播媒介银足白蛉。
