印度西高止山脉内脏利什曼病和皮肤利什曼病的致病因利什曼原虫的遗传多样性。
Genetic diversity of Leishmania donovani causing visceral and cutaneous leishmaniasis in the Western Ghats, India.
机构信息
Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India.
Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India.
出版信息
Gene. 2024 Nov 30;928:148803. doi: 10.1016/j.gene.2024.148803. Epub 2024 Jul 27.
The visceral and atypical cutaneous leishmaniasis (VL and CL) caused by Leishmania donovani is an emerging infectious disease in the Western Ghats, Kerala, India. In this study, L. donovani specific kinetoplast minicircle DNA (k-DNA) sequence analysis was conducted to ascertain the genetic variability among the L. donovani isolates from the Western Ghats. Out of 23 CL and 5 VL suspected patient samples, 18 CL and 3 VL tested positive for k-DNA diagnostic PCR. Subsequently, 17 CL and 3 VL samples were found positive for L. donovani specific k-DNA PCR. Although the genetic diversity among the VL and CL isolates was low, there was clear variation from the parasites reported from other countries. The parasites characterized from the current study were more related to those reported from East Africa and India.
印度喀拉拉邦西高止山脉的内脏利什曼病（VL）和皮肤利什曼病（CL）由杜氏利什曼原虫引起，是一种新出现的传染病。在这项研究中，对杜氏利什曼原虫特异性动基体微小染色体 DNA（k-DNA）序列进行了分析，以确定来自西高止山脉的杜氏利什曼原虫分离株之间的遗传变异性。在 23 例 CL 和 5 例 VL 疑似患者样本中，18 例 CL 和 3 例 VL 对 k-DNA 诊断 PCR 呈阳性。随后，17 例 CL 和 3 例 VL 样本对杜氏利什曼原虫特异性 k-DNA PCR 呈阳性。尽管 VL 和 CL 分离株之间的遗传多样性较低，但与来自其他国家的寄生虫有明显的差异。从本研究中鉴定出的寄生虫与来自东非和印度的寄生虫更为相关。
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