Fathima P A, Shah Harish Kumar, Aiswarya R S, Ajithlal P M, Shailaja T V, Shubin C, Reena K J, Saini Prasanta
Indian Council of Medical Research - Vector Control Research Centre (Field Station), Kottayam 686003, India.
District Government Hospital, Nilambur, Malappuram 679329, India.
Trans R Soc Trop Med Hyg. 2025 Apr 1;119(4):393-395. doi: 10.1093/trstmh/trae102.
Different clinical manifestations of leishmaniasis (cutaneous and visceral) caused by Leishmania donovani have been reported from Kerala, India. Leishmania donovani causing cutaneous leishmaniasis (CL) (also called atypical CL [ACL]) is one of the major health concerns in the Western Ghats belt of the state.
Skin biopsies of 20 patients with suspected CL from Nilambur, Kerala, were processed for CL diagnosis during the period 2022-2023. Parasite species were characterized using Leishmania-specific Internal Transcribed Spacer-Ⅰ (ITS-Ⅰ) PCR and ITS-Ⅰ RFLP analysis.
A total of 18 cases were confirmed to be CL and the parasite was identified as L. donovani.
These indigenous ACL (CL due to L. donovani) reports from the small foci of Nilambur reveal an emerging endemic zone of leishmaniasis in the Western Ghats.
印度喀拉拉邦已报告由杜氏利什曼原虫引起的利什曼病（皮肤型和内脏型）有不同临床表现。引起皮肤利什曼病（CL）（也称为非典型CL [ACL]）的杜氏利什曼原虫是该邦西高止山脉地区的主要健康问题之一。
2022年至2023年期间，对来自喀拉拉邦尼尔阿姆布尔的20例疑似CL患者的皮肤活检样本进行处理以诊断CL。使用利什曼原虫特异性内转录间隔区-Ⅰ（ITS-Ⅰ）PCR和ITS-Ⅰ RFLP分析对寄生虫种类进行鉴定。
共18例确诊为CL，寄生虫被鉴定为杜氏利什曼原虫。
这些来自尼尔阿姆布尔小疫源地的本土ACL（由杜氏利什曼原虫引起的CL）报告揭示了西高止山脉一个新出现的利什曼病流行区。
