Rostain J C, Wardley-Smith B, Halsey M J, Nunn J F
Undersea Biomed Res. 1986 Dec;13(4):407-11.
Male Sprague-Dawley rats were compressed in helium-oxygen mixture at a rate of 3 bar/min. Compression ended once the first convulsion was seen. Saline or barbituric acid at 1 or 2% were infused continuously during compression at a rate of 9.49 ml/h (tail vein). With barbituric acid at 1%, coarse tremor and convulsions appeared at higher pressures than in saline controls. No significant change was observed with 2% barbituric acid compared to saline controls. Barbituric acid which is nonanesthetic had some anti-high pressure nervous syndrome (HPNS) activity which is dose dependent. These results suggest that anti-HPNS activity of these different compounds involves at least one site which is different from that responsible for anesthetic activity.
雄性斯普拉格-道利大鼠在氦氧混合气体中以每分钟3巴的速度进行压缩。一旦观察到首次惊厥，压缩即停止。在压缩过程中，以9.49毫升/小时的速度（经尾静脉）持续输注生理盐水或1%或2%的巴比妥酸。使用1%的巴比妥酸时，与生理盐水对照组相比，在更高的压力下出现了粗大震颤和惊厥。与生理盐水对照组相比，2%的巴比妥酸未观察到显著变化。非麻醉性的巴比妥酸具有一定的抗高压神经综合征（HPNS）活性，且呈剂量依赖性。这些结果表明，这些不同化合物的抗HPNS活性涉及至少一个与麻醉活性所涉及的位点不同的位点。
