Lightfoot E N, Rudolph R F, Lenhoff A M, Lanphier E H, Lehner C E, Whiteside L A
Undersea Biomed Res. 1986 Dec;13(4):425-41.
Residence time distributions of hydrogen in bone of anesthetized dogs and rabbits were used to estimate local blood perfusion rates and to characterize the important transport processes taking place. The hydrogen was administered by inhalation, and the concentrations in the bone were measured by embedded platinum microelectrodes. Mean residence times varied significantly both with position and time, and it was found preferable to calculate residence time from moments of the residence time distribution rather than the downslope method. Moreover, the downslope on a semilogarithmic scale continued to decrease with the increase in observation time. For the tissue investigated, simple compartmental models are inadequate even for the small regions characterized by the electrodes. This means that a large number of Haldanian compartments are needed even to characterize local washout behavior. The significance of this finding for the selection of decompression schedules is briefly discussed.
利用麻醉犬和兔骨骼中氢气的停留时间分布来估计局部血液灌注率，并描述发生的重要传输过程。氢气通过吸入给药，骨骼中的浓度通过嵌入式铂微电极测量。平均停留时间随位置和时间变化显著，发现从停留时间分布的矩而不是下坡法计算停留时间更可取。此外，半对数尺度上的下坡随观察时间的增加而持续下降。对于所研究的组织，即使对于由电极表征的小区域，简单的房室模型也不够。这意味着即使要表征局部清除行为也需要大量的哈代房室。简要讨论了这一发现对减压方案选择的意义。
