Whiteside L A, Lesker P A, Simmons D J
Clin Orthop Relat Res. 1977 Jan-Feb(122):340-6.
This study tested the feasibility of using the hydrogen washout technique for measuring regional bone and bone marrow blood flow. Washout curves in cancellous and cortical bone were mono-exponential, indicating homogeneous perfusion of these tissues. Epiphyseal cancellous bone blood flow (0.129 +/- 0.015 ml/min/ml) and metaphyseal cancellous bone blood flow (0.170 +/- 0.014 ml/min/ml) were approximately twice as rapid as that of cortical bone (0.069 +/- 0.002 ml/min/ml). Washout of hydrogen from bone marrow was variable and usually formed a bi-exponential pattern, indicating non-homogeneous perfusion. Blood flow rate determined by analyzing the rapid components was 1.04 +/- 0.10 ml/min/ml, and that from the slow components was 0.27 +/- 0.02 ml/min/ml. Our blood flow rates are within the range of values reported by investigators using different methods, and the hydrogen washout technique offers specificity and ease of repetitive determinations not available with other methods.
本研究测试了使用氢洗脱技术测量局部骨和骨髓血流的可行性。松质骨和皮质骨的洗脱曲线呈单指数形式，表明这些组织灌注均匀。骨骺松质骨血流（0.129±0.015毫升/分钟/毫升）和干骺端松质骨血流（0.170±0.014毫升/分钟/毫升）大约是皮质骨血流（0.069±0.002毫升/分钟/毫升）的两倍。骨髓中氢的洗脱情况各异，通常呈双指数模式，表明灌注不均匀。通过分析快速成分确定的血流速率为1.04±0.10毫升/分钟/毫升，通过慢速成分确定的血流速率为0.27±0.02毫升/分钟/毫升。我们的血流速率在使用不同方法的研究者所报告的值范围内，并且氢洗脱技术具有特异性，且易于重复测定，这是其他方法所不具备的。
