Hedenström H, Malmberg P, Fridriksson H V
Ups J Med Sci. 1986;91(3):299-310. doi: 10.3109/03009738609178670.
Prediction formulas for static and dynamic spirometry, gas distribution, static lung mechanics and the transfer test were derived from measurements in healthy men. The measurements included total lung capacity, residual volume, airways resistance, static elastic recoil pressure of the lung, static compliance, closing volume, slope of the alveolar plateau (phase III), flow-volume variables (including mean transit time) during breathing of air or a helium/oxygen mixture, and conventional spirometric indices. The results from 146 smokers and 124 never-smokers were evaluated separately and combined. For all lung function tests a single regression equation was obtained. The prediction formulas included time-related smoking variables and were valid for both smokers and never-smokers. For many lung function tests, a nonlinear age coefficient resulted in a significant reduction in variance compared with simple linear models. Heavy tobacco smoking influenced most lung function tests less than ageing from 20 to 70 years, but for airways resistance, transfer factor and phase III the opposite was found.
静态和动态肺量测定、气体分布、静态肺力学以及换气功能试验的预测公式源自对健康男性的测量。测量内容包括肺总量、残气量、气道阻力、肺的静态弹性回缩压、静态顺应性、闭合气量、肺泡平台（第三相）斜率、空气或氦/氧混合气呼吸期间的流量-容积变量（包括平均通过时间）以及传统肺量测定指标。分别对146名吸烟者和124名从不吸烟者的结果进行了评估，并将二者合并。对于所有肺功能测试，均获得了一个单一回归方程。预测公式包含与时间相关的吸烟变量，对吸烟者和从不吸烟者均有效。对于许多肺功能测试，与简单线性模型相比，非线性年龄系数使方差显著降低。重度吸烟对大多数肺功能测试的影响小于20至70岁的年龄增长，但对于气道阻力、转移因子和第三相，情况则相反。
