Dündar Sema, Yaşar Mimbay, Çakmak Harun, Kıylıoğlu Nefati, Ünsal Alparslan
Ophthalmology, Adnan Menderes University, Faculty of Medicine, Aydın, Turkey.
Ophthalmology, Bingöl State Hospital, Bingöl, Turkey.
GMS Ophthalmol Cases. 2023 Dec 12;13:Doc24. doi: 10.3205/oc000232. eCollection 2023.
To present a case with infliximab-induced retrobulbar optic neuritis.
A 58-year-old woman presented to our clinic with a two-day history of blurred vision in her right eye. She had numerous uveitis attacks previously, and she was on infliximab treatment for ankylosing spondylitis. Her best-corrected visual acuity was counting fingers and 20/25 in the right and left eye, respectively. Optic discs seemed healthy in fundoscopic examination. The right optic nerve showed high signal intensity on magnetic resonance imaging (MRI). Infliximab treatment was discontinued and systemic steroid therapy was started. After the treatment her best-corrected visual acuity improved to 20/20 in her right eye.
Infliximab is a chimeric human-murine monoclonal antibody used in autoimmune diseases. Optic neuritis is a rare but important side effect of infliximab. Thus, infliximab-induced optic neuritis should be kept in mind for patients receiving infliximab treatment.
报告1例英夫利昔单抗诱发的球后视神经炎病例。
一名58岁女性因右眼视力模糊2天前来我院就诊。她既往有多次葡萄膜炎发作史，因强直性脊柱炎正在接受英夫利昔单抗治疗。她的最佳矫正视力右眼为指数，左眼为20/25。眼底镜检查显示视盘看起来正常。磁共振成像（MRI）显示右侧视神经呈高信号强度。停用英夫利昔单抗治疗并开始全身类固醇治疗。治疗后，她右眼的最佳矫正视力提高到20/20。
英夫利昔单抗是一种用于自身免疫性疾病的嵌合型人鼠单克隆抗体。视神经炎是英夫利昔单抗罕见但重要的副作用。因此，接受英夫利昔单抗治疗的患者应牢记英夫利昔单抗诱发的视神经炎。
