Research Center for Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
Molecular Imaging and Therapy Research Unit, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Stem Cell Rev Rep. 2023 Jul;19(5):1214-1231. doi: 10.1007/s12015-023-10539-9. Epub 2023 Apr 14.
Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research.
间充质干细胞（MSCs）因其多能性和在不同疾病中表现出强大而多样的功能，被认为是同种异体细胞治疗的极具前景的细胞。MSCs 的功能，包括天然免疫调节、高自我更新特性以及分泌和营养特性，可用于改善疾病中的免疫调节功能。MSCs 通过直接接触和/或分泌正的微环境因素来影响大多数免疫细胞，从而影响它们。先前的研究报告称，MSCs 的免疫调节作用基本上取决于其从 MSCs 中的分泌能力。本综述讨论了 MSCs 的免疫调节能力以及有希望的策略，以成功提高 MSCs 在临床研究中的潜在利用。
