Department of Hematology, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Hum Vaccin Immunother. 2023 Dec 15;19(3):2291900. doi: 10.1080/21645515.2023.2291900. Epub 2023 Dec 19.
CAR-T cell therapy has demonstrated efficacy in treating certain hematological malignancies. However, the administration of CAR-T cells is accompanied by the occurrence of adverse events. Among these, cytokine release syndrome (CRS) has garnered significant attention. In this descriptive study, we set the search criteria to retrieve and obtain articles regarding CAR-T cell-related CRS from the Web of Science Core Collection (WoSCC). The bibliometric and knowledge-map analysis of these documents was conducted using Microsoft Excel 2019, GraphPad Prism 8, CtieSpace, and VOSviewer. 6,623 authors from 295 institutions in 49 countries coauthored a total of 1,001 publications. The leading country in this field was the United States. The most productive institution was the University of Pennsylvania. Carl H. June had the most citations, while Daniel W. Lee had the most co-citations. Research hotspots primarily concentrated on the pathogenesis, serum biomarkers, management, and therapeutic drugs of CRS, alongside neurotoxicity. Emerging topics within this discipline encompassed the following: a. Drugs for effective treatment and intervention of CRS; b. Conducting pertinent clinical trials to acquire real-world data; c. Management of toxicity (CRS and neurotoxicity) associated with CAR-T cell therapy; d. The study of BCMA-CAR-T cells in multiple myeloma (MM); e. Optimizing the CAR framework structure to enhance the effectiveness and safety of CAR-T cells. A bibliometric and scientific knowledge-map analysis provided a unique and objective perspective for exploring the field of CAR-T cell-related CRS, and may provide some new clues and valuable references for researchers.
嵌合抗原受体 T 细胞（CAR-T）疗法在治疗某些血液系统恶性肿瘤方面显示出疗效。然而，CAR-T 细胞的给药伴随着不良反应的发生。其中，细胞因子释放综合征（CRS）引起了广泛关注。在本描述性研究中，我们设定了搜索标准，从 Web of Science 核心合集（WoSCC）中检索并获得了与 CAR-T 细胞相关 CRS 的文章。使用 Microsoft Excel 2019、GraphPad Prism 8、Citespace 和 VOSviewer 对这些文献进行了文献计量和知识图谱分析。来自 49 个国家的 295 个机构的 6623 位作者共同撰写了 1001 篇出版物。该领域的领先国家是美国。最多产的机构是宾夕法尼亚大学。Carl H. June 被引用次数最多，而 Daniel W. Lee 被共同引用次数最多。研究热点主要集中在 CRS 的发病机制、血清生物标志物、管理和治疗药物以及神经毒性上。该学科的新兴主题包括：a. 有效治疗和干预 CRS 的药物；b. 开展相关临床试验以获取真实世界数据；c. 管理 CAR-T 细胞治疗相关的毒性（CRS 和神经毒性）；d. 在多发性骨髓瘤（MM）中研究 BCMA-CAR-T 细胞；e. 优化 CAR 框架结构，提高 CAR-T 细胞的有效性和安全性。文献计量和科学知识图谱分析为探索 CAR-T 细胞相关 CRS 领域提供了独特而客观的视角，并可能为研究人员提供一些新的线索和有价值的参考。
