Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
Chinese PLA Medical School Beijing, Beijing, China.
Front Immunol. 2022 Aug 12;13:969196. doi: 10.3389/fimmu.2022.969196. eCollection 2022.
As emerging adoptive immunotherapy after CAR-T cell therapy, CAR-NK cell therapy has been developing rapidly in recent years. Presently, the research on CAR-NK cells has become a hotspot in the field of tumor immunotherapy.
In this descriptive study, CtieSpace and VOSviewer were used to perform the bibliometric and scientific knowledge-map analysis of articles and reviews related to CAR-NK cells.
5371 authors from 715 institutions in 65 countries published 1028 papers about CAR-NK cells in 346 journals. The number of publications related to CAR-NK cells was increasing overall, especially from 2018 to 2021. The United States was in a leading position. The most active institution was Univ Texas, MD Anderson Cancer Center (USA). The journal with the most publications was , and the most co-cited journal was . The researcher with the most published papers was Winfried S. Wels, while the most co-cited researcher was Shannon L Maude. The research of CAR-NK cells in hematological malignancies and solid tumors (especially the selection of targets and the evaluation of efficacy and safety) was a research hotspot in this field. The emerging topics mainly included three aspects. First, further improve the proliferation and persistence of NK cells . Secondly, optimizing and improving the CAR structure for NK cells to improve the anti-tumor ability of CAR-NK cells. Thirdly, the related research of CRISPR/Cas9 gene-editing technology in constructing engineered immune cells.
In this study, a bibliometric and scientific knowledge-map study provided a unique and objective perspective for the CAR-NK cell field. This information would provide a helpful reference for researchers interested in this field.
作为 CAR-T 细胞治疗后的新兴过继免疫疗法，CAR-NK 细胞治疗近年来发展迅速。目前，CAR-NK 细胞的研究已成为肿瘤免疫治疗领域的热点。
本研究采用 Citespace 和 VOSviewer 对 CAR-NK 细胞相关的文章和综述进行文献计量学和科学知识图谱分析。
来自 715 家机构的 5371 位作者在 346 种期刊上发表了 1028 篇关于 CAR-NK 细胞的论文。总体而言，与 CAR-NK 细胞相关的出版物数量呈增长趋势，尤其是 2018 年至 2021 年。美国处于领先地位，最活跃的机构是美国德克萨斯大学 MD 安德森癌症中心。发表论文最多的期刊是《自然评论免疫学》，被引频次最高的期刊是《柳叶刀肿瘤学》。发表论文最多的研究人员是 Winfried S. Wels，被引频次最高的研究人员是 Shannon L. Maude。CAR-NK 细胞在血液恶性肿瘤和实体瘤（尤其是靶点选择和疗效及安全性评价）的研究是该领域的研究热点。新兴主题主要包括三个方面：第一，进一步提高 NK 细胞的增殖和持久性；第二，优化和改进 CAR 结构，提高 CAR-NK 细胞的抗肿瘤能力；第三，CRISPR/Cas9 基因编辑技术在构建工程免疫细胞方面的相关研究。
本研究通过文献计量学和科学知识图谱分析，为 CAR-NK 细胞领域提供了独特而客观的视角。这些信息将为该领域的研究人员提供有益的参考。
