School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.
Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, P. R. China.
Adv Healthc Mater. 2024 Mar;13(8):e2303215. doi: 10.1002/adhm.202303215. Epub 2023 Dec 25.
Topical therapy has received worldwide attention for in situ tumors owing to its higher efficacy of drug delivery. Herein, this work reports a dissolvable multifunctional hyaluronic acid microneedles (HMNs) patch coloaded with temozolomide (TMZ) and MnCl (TMZ/MnCl@HMN) for chemoimmunotherapy of melanoma. HMNs can ensure the stability of TMZ over time, and exhibit fewer side effects with a localized release way. In particular, TMZ not only promotes dendritic cell maturation by triggering immunogenic cell death in tumor cells, but also induces DNA damage that can further enhance the Mn-activated cGAS-STING (stimulator of interferon genes pathway). As a result, the TMZ/MnCl@HMN multifunctional platform significantly inhibits lung metastases for melanoma, providing a practical strategy for precision therapy of melanoma.
局部治疗因其药物输送的更高效率而受到原位肿瘤的全球关注。在此，本工作报道了一种可溶解的多功能透明质酸微针（HMN）贴片，共载有替莫唑胺（TMZ）和 MnCl（TMZ/MnCl@HMN），用于黑色素瘤的化学免疫治疗。HMN 可以确保 TMZ 随时间的稳定性，并通过局部释放方式表现出更少的副作用。特别是，TMZ 通过触发肿瘤细胞中的免疫原性细胞死亡来促进树突状细胞成熟，同时也诱导 DNA 损伤，这可以进一步增强 Mn 激活的 cGAS-STING（干扰素基因途径的刺激物）。结果，TMZ/MnCl@HMN 多功能平台显著抑制黑色素瘤的肺转移，为黑色素瘤的精准治疗提供了一种实用策略。
