Li Yan-Yu, Yuan Chen-Chen, Cai Ai-Yuan, Zhou Bo-Ju, Huang Teng
Department of Pediatrics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China (Huang T, Email: 33431640@qq. com).
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Dec 15;25(12):1219-1226. doi: 10.7499/j.issn.1008-8830.2306097.
To systematically evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting coronary artery lesions (CAL) in Chinese children with Kawasaki Disease (KD).
A comprehensive search was conducted in databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database from inception to December 2022. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and a Meta analysis was performed using Stata 15.1.
A total of ten published reports, involving 3 664 Chinese children with KD, were included in this Meta analysis, of whom 1 328 developed CAL. The Meta analysis revealed a sensitivity of 0.78 (95%: 0.71-0.83), specificity of 0.71 (95%: 0.61-0.80), overall diagnostic odds ratio of 8.69 (95%: 5.02-15.06), and an area under the curve of the summary receiver operating characteristic of 0.82 (95%: 0.78-0.85) for PLR in predicting CAL in the children with KD. The sensitivity, specificity, and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators. Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies. However, a significant publication bias was observed (<0.001).
PLR demonstrates certain predictive value for CAL in Chinese children with KD.
系统评价血小板与淋巴细胞比值（PLR）对中国川崎病（KD）患儿冠状动脉病变（CAL）的预测价值。
对PubMed、Embase、Cochrane图书馆、Web of Science、中国知网、万方数据、中国生物医学文献数据库和中国科技期刊数据库等数据库进行全面检索，检索时间从建库至2022年12月。采用纽卡斯尔-渥太华量表评估纳入文献的质量，并使用Stata 15.1进行Meta分析。
本Meta分析共纳入10篇已发表报告，涉及3664例中国KD患儿，其中1328例发生CAL。Meta分析显示，PLR预测KD患儿CAL的敏感度为0.78（95%：0.71-0.83），特异度为0.71（95%：0.61-0.80），总体诊断比值比为8.69（95%：5.02-15.06），汇总受试者工作特征曲线下面积为0.82（95%：0.78-0.85）。与PLR联合其他指标相比，单独PLR的敏感度、特异度和汇总受试者工作特征曲线下面积较低。敏感性分析表明Meta分析结果具有稳定性，排除个别研究后无显著变化。然而，观察到显著的发表偏倚（<0.001）。
PLR对中国KD患儿的CAL具有一定的预测价值。
