Jalasto Juuso, Luukkonen Ritva, Lindqvist Ari, Langhammer Arnulf, Kankaanranta Hannu, Backman Helena, Rönmark Eva, Sovijärvi Anssi, Piirilä Päivi, Kauppi Paula
Department of Clinical Physiology, HUS Medical Diagnostic Center, Helsinki University Central Hospital and University of Helsinki, PL 281, 00029 HUS, Helsinki, Finland.
Finnish Institute of Occupational Health, Helsinki, Finland.
Int Arch Occup Environ Health. 2024 Mar;97(2):145-154. doi: 10.1007/s00420-023-02031-1. Epub 2023 Dec 19.
Environmental particulate matter (PM) exposure has been shown to cause excess all-cause and disease-specific mortality. Our aim was to compare disease-specific mortality by estimated occupational exposure to vapors, gasses, dusts, and fumes (VGDF).
The data source is the Helsinki part of the population-based FinEsS study on chronic obstructive pulmonary diseases including information on age, education level, main occupation, sex, and tobacco smoking combined with death registry information. We compared estimated VGDF exposure to mortality using adjusted competing-risks regression for disease-specific survival analysis for a 24-year follow-up.
Compared to the no-exposure group, the high occupational VGDF exposure group had sub-hazard ratios (sHR) of 1.7 (95% CI 1.3-2.2) for all cardiovascular-related and sHR 2.1 (1.5-3.9) for just coronary artery-related mortality. It also had sHR 1.7 (1.0-2.8) for Alzheimer's or vascular dementia-related mortality and sHR 1.7(1.2-2.4) for all respiratory disease-related mortality.
Long-term occupational exposure to VGDF increased the hazard of mortality- to cardiovascular-, respiratory-, and dementia-related causes. This emphasizes the need for minimizing occupational long-term respiratory exposure to dust, gasses, and fumes.
环境颗粒物（PM）暴露已被证明会导致全因死亡率和特定疾病死亡率上升。我们的目的是比较通过估计职业暴露于蒸气、气体、粉尘和烟雾（VGDF）导致的特定疾病死亡率。
数据来源是基于人群的芬兰慢性阻塞性肺疾病研究（FinEsS）的赫尔辛基部分，其中包括年龄、教育水平、主要职业、性别和吸烟信息，并与死亡登记信息相结合。我们使用调整后的竞争风险回归对特定疾病生存分析进行了24年随访，以比较估计的VGDF暴露与死亡率。
与未暴露组相比，高职业VGDF暴露组所有心血管相关死亡率的亚危险比（sHR）为1.7（95%CI 1.3 - 2.2），仅冠状动脉相关死亡率的sHR为2.1（1.5 - 3.9）。阿尔茨海默病或血管性痴呆相关死亡率的sHR为1.7（1.0 - 2.8），所有呼吸道疾病相关死亡率的sHR为1.7（1.2 - 2.4）。
长期职业暴露于VGDF会增加心血管、呼吸和痴呆相关病因导致的死亡风险。这强调了尽量减少职业长期呼吸道暴露于粉尘、气体和烟雾的必要性。
