Dekutovich G V, Kargapolov A V
Vopr Med Khim. 1986 Nov-Dec;32(6):38-41.
Effect of local anesthetics on phospholipid composition was studied in rat liver mitochondria incubated in hypotonic solution of sucrose. Administration of trimecaine hydrochloride caused active hydrolysis of cardiolipin (CL), while destruction of phosphatidyl choline (PC), phosphatidyl ethanolamine (PEA), lysophosphatidyl choline (LPC), lysophosphatidyl ethanolamine (LPE) and lysocardiolipin (LCL) was inhibited. In the mixture containing tetracaine hydrochloride hydrolysis of PEA, LPC and LCL was decreased; dibucaine hydrochloride caused hydrolysis of CL and LPC, whereas PC was not hydrolyzed. The data obtained suggest that local anesthetics, dissimilar in their physico-chemical properties, exhibited specific effect on phospholipid spectrum of mitochondrial membranes.
