[Effect of electric stimulation of the hypothalamus on the transcription activity of chromatin in the rat liver during aging].

Age-dependent peculiarities of electric stimulation of hypothalamus were studied by means of estimation of active/inactive liver chromatin fractions, protein/DNA ratio in the latters, level of incorporation of 14C-orotic acid in total RNA and in chromatin RNA fractions. Electric stimulation of hypothalamus in adult rats led to an increase in the relative content of active chromatin fraction and in the rate of the labelled precursor incorporation into both chromatin fractions. In old animals the stimulation did not cause any redistribution of chromatin fractions and did not affect the rate of the labelled precursor incorporation into RNA. These data showed that hypothalamic control of the chromatin status was altered during ageing.