Mozzhukhina T G, Khilobok I Iu, Gol'dshtein N B
Ukr Biokhim Zh (1978). 1982;54(1):73-6.
The structure and biological activity (the level of the labelled precursor incorporation into RNA) of active and repressed chromatin of the liver and small intestine mucosa were studied in adult (6-8 months) and old (24-26 months) rats. The content of repressed chromatin fraction in both tissues is found to increase with age. In the liver of old rats the level of [14C[ orotic acid incorporation into RNA of chromatin fractions decreases, radioactivity of the acid-soluble fraction being unchanged. In the small intestine mucosa a high leve of [14C] orotic acid incorporation into chromatin RNA with ageing is due to an increase in permeability of the mucosa cells.
研究了成年（6 - 8个月）和老年（24 - 26个月）大鼠肝脏和小肠黏膜活性染色质与抑制染色质的结构及生物活性（标记前体掺入RNA的水平）。发现这两种组织中抑制染色质部分的含量均随年龄增长而增加。在老年大鼠的肝脏中，染色质部分RNA中[¹⁴C]乳清酸的掺入水平降低，而酸溶性部分的放射性不变。在小肠黏膜中，随着衰老，[¹⁴C]乳清酸掺入染色质RNA的水平较高是由于黏膜细胞通透性增加所致。
