Prozorovskaia N N, Glinianaia S V, Del'vig A A
Vopr Med Khim. 1986 Nov-Dec;32(6):84-6.
Age-dependent alterations in excretion of hydroxyproline were studied in 62 healthy persons (3-78 years old) by means of analysis of the morning portion of urine after gel filtration on Sephadex G-10. With ageing the following patterns were decreased: content of total hydroxyproline (r = -0.78; P less than 0.001), the ratio hydroxyproline/creatinine (r = -0.80, P less than 0.001) and content of hydroxyproline in peptide fraction with MW greater than 700-1000 (r = -0.50; P less than 0.001). The reverse correlation was found between the contents of total and free hydroxyproline (r = -0.45; P less than 0.001) but total content of hydroxyproline correlated directly with its content in the peptide fraction (r = 0.92; P less than 0.001). At the same time, reverse correlation was observed between the contents of free hydroxyproline and of the peptide-bound amino acid (r = -0.58; P less than 0.001). Approximate ranges of normal excretion of hydroxyproline with urine were calculated in various age groups.
通过对62名健康人（3至78岁）经Sephadex G - 10凝胶过滤后的晨尿进行分析，研究了羟脯氨酸排泄的年龄依赖性变化。随着年龄增长，出现下降的指标有：总羟脯氨酸含量（r = -0.78；P < 0.001）、羟脯氨酸/肌酐比值（r = -0.80，P < 0.001）以及分子量大于700 - 1000的肽段部分中的羟脯氨酸含量（r = -0.50；P < 0.001）。总羟脯氨酸与游离羟脯氨酸含量之间呈负相关（r = -0.45；P < 0.001），但总羟脯氨酸含量与其在肽段部分中的含量呈正相关（r = 0.92；P < 0.001）。同时，游离羟脯氨酸含量与肽结合氨基酸含量之间呈负相关（r = -0.58；P < 0.001）。计算了不同年龄组尿液中羟脯氨酸正常排泄的大致范围。
