Department of Behavioural Science and Health, University College London, London, UK.
SPECTRUM Consortium, London, UK.
Sci Rep. 2023 Dec 19;13(1):22676. doi: 10.1038/s41598-023-49602-3.
Nicotine vaping products (NVPs) and heated tobacco products (HTPs) are designed to replicate the sensory and behavioural aspects of smoking cigarettes while avoiding combustion. The success of these products as harm reduction tools will partially depend on their ability to satisfy smokers and alleviate nicotine-related withdrawal symptoms. This study aims to compare short-term effects of NVPs (Juul and Aspire PockeX) versus HTPs (IQOS) on smoking-related withdrawal relief, product satisfaction, intention to switch to NVP/HTP, perceptions and attitudes in UK adult cigarette smokers naïve to these products. In a randomized cross-over study, 45 participants visited the lab twice, at each visit trying one of the two products (NVP/HTP) and completing a questionnaire. Responses were normalized on a 0-100% scale and mean differences (MD) between NVP and HTP scores computed, with positive and negative MD values indicating greater endorsement for NVP and HTP, respectively. Cigarette cravings were reduced similarly (~ 20.0%) by both products (MD = 4.5%, 95%Confidence Interval (CI) - 4.8, 13.8). Direct positive effects (MD = - 3.5%, 95%CI - 7.2, 0.2) and adverse side effects (MD = 1.8%, 95%CI - 0.3, 3.8) were comparable after each product use, though marginally favouring HTPs. HTPs were perceived as more satisfying overall (MD = - 13.2%, 95%CI - 20.3 - 6.1) than NVPs but both were perceived as similarly addictive (MD = 3.6%, 95%CI - 4.6, 11.8), relative to cigarettes. Intention to switch to either product was comparable (MD = 4.0%, 95%CI - 5.7, 13.8). Comparison of acute use of NVP versus HTP in a sample of UK smokers naïve to these products suggests that HTPs are perceived as more satisfying than NVPs, though still less satisfying than cigarettes.Registration: The analysis plan was pre-registered, and it is available at https://osf.io/6ymdu.
尼古丁雾化产品（NVPs）和加热烟草产品（HTPs）旨在复制吸烟的感官和行为方面，同时避免燃烧。这些产品作为减少伤害的工具的成功，将部分取决于它们满足吸烟者和缓解尼古丁戒断症状的能力。本研究旨在比较 NVPs（Juul 和 Aspire PockeX）与 HTPs（IQOS）对吸烟相关戒断缓解的短期影响，评估英国成年吸烟人群对这些产品的满意度、转换使用这些产品的意愿、对这些产品的看法和态度，这些参与者对这些产品均不熟悉。在一项随机交叉研究中，45 名参与者两次访问实验室，每次访问尝试两种产品（NVP/HTP）之一，并完成一份问卷。用 0-100%的标度对回答进行归一化，计算 NVP 和 HTP 得分之间的平均差异（MD），正值 MD 表示对 NVP 的更高支持，负值 MD 表示对 HTP 的更高支持。两种产品都能相似地降低约 20.0%的香烟渴求感（MD=4.5%，95%置信区间（CI）-4.8，13.8）。使用每种产品后的直接积极影响（MD=-3.5%，95%CI-7.2，0.2）和不良反应（MD=1.8%，95%CI-0.3，3.8）相当，但略微有利于 HTP。HTPs 总体上被认为更令人满意（MD=-13.2%，95%CI-20.3-6.1），而 NVPs 则被认为更令人上瘾（MD=3.6%，95%CI-4.6，11.8），与香烟相比。两种产品的转换意愿相当（MD=4.0%，95%CI-5.7，13.8）。在对这些产品均不熟悉的英国吸烟者样本中，比较 NVPs 与 HTP 的急性使用情况表明，HTPs 被认为比 NVPs 更令人满意，但仍不如香烟令人满意。
分析计划已预先注册，可在 https://osf.io/6ymdu 上获取。
