• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Central Role of pH in the Clinical Pharmacology of Nicotine: Implications for Abuse Liability, Cigarette Harm Reduction and FDA Regulation.

作者信息

Benowitz Neal L

机构信息

Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, and Center for Tobacco Control Research and Education, University of California, San Francisco, California, USA.

出版信息

Clin Pharmacol Ther. 2022 May;111(5):1004-1006. doi: 10.1002/cpt.2555. Epub 2022 Feb 27.

DOI:10.1002/cpt.2555
PMID:35220591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9035094/
Abstract
摘要

相似文献

1
The Central Role of pH in the Clinical Pharmacology of Nicotine: Implications for Abuse Liability, Cigarette Harm Reduction and FDA Regulation.pH在尼古丁临床药理学中的核心作用：对成瘾可能性、减少香烟危害及美国食品药品监督管理局监管的影响
Clin Pharmacol Ther. 2022 May;111(5):1004-1006. doi: 10.1002/cpt.2555. Epub 2022 Feb 27.
2
Blood Nicotine Predicts the Behavioral Economic Abuse Liability of Reduced-Nicotine Cigarettes.血液尼古丁可预测低尼古丁卷烟的行为经济学滥用倾向。
Nicotine Tob Res. 2022 Mar 26;24(5):728-735. doi: 10.1093/ntr/ntab227.
3
Australian urban Indigenous smokers' perspectives on nicotine products and tobacco harm reduction.澳大利亚城市原住民烟民对尼古丁产品和烟草减害的看法。
Drug Alcohol Rev. 2018 Jan;37(1):87-96. doi: 10.1111/dar.12549. Epub 2017 May 10.
4
Human Abuse Liability Assessment of Tobacco and Nicotine Products: Approaches for Meeting Current Regulatory Recommendations.烟草和尼古丁产品的人类滥用风险评估：满足当前监管建议的方法
Nicotine Tob Res. 2022 Feb 14;24(3):295-305. doi: 10.1093/ntr/ntab183.
5
Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers.四种口味 JUUL 系统相对于可燃香烟、尼古丁口香糖和一种比较电子尼古丁输送系统在成年吸烟者中的滥用倾向评估。
Drug Alcohol Depend. 2020 Dec 1;217:108395. doi: 10.1016/j.drugalcdep.2020.108395. Epub 2020 Nov 4.
6
Tobacco control policies should embrace harm reduction products, nicotine experts say.尼古丁专家表示，烟草控制政策应涵盖减害产品。
BMJ. 2014 May 29;348:g3604. doi: 10.1136/bmj.g3604.
7
Paying more attention to the 'elephant in the room'.更加关注房间里的大象。 （注：“房间里的大象”是个隐喻，指那些触目惊心的存在却被明目张胆地忽略、甚至否定的事实或者感受等 ）
Tob Control. 2017 Mar;26(e1):e35-e36. doi: 10.1136/tobaccocontrol-2016-053150. Epub 2016 Jun 29.
8
Abuse liability assessment of the JUUL system in two nicotine concentrations compared to combustible cigarette, nicotine gum and comparator electronic nicotine delivery system.两种浓度 JUUL 系统与可燃香烟、尼古丁咀嚼胶和对照电子烟相比的滥用倾向评估。
Drug Alcohol Depend. 2020 Dec 1;217:108441. doi: 10.1016/j.drugalcdep.2020.108441. Epub 2020 Nov 24.
9
Nicotine and health.尼古丁与健康。
Drug Ther Bull. 2014 Jul;52(7):78-81. doi: 10.1136/dtb.2014.7.0264.
10
Tobacco, nicotine and harm reduction.烟草、尼古丁与危害降低。
Drug Alcohol Rev. 2011 Mar;30(2):119-23. doi: 10.1111/j.1465-3362.2010.00264.x.

引用本文的文献

1
Nicotine from a Different Angle: Biological Effects from a Psychoneuroimmunological Perspective.从不同角度看尼古丁：心理神经免疫学视角下的生物学效应
Int J Mol Sci. 2025 Jul 4;26(13):6437. doi: 10.3390/ijms26136437.
2
Oral Nicotine Pouches: Rising Popularity and State of the Science.口服尼古丁袋：日益普及与科学现状
Public Health Rep. 2025 Apr 28:333549251313668. doi: 10.1177/00333549251313668.
3
Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective.用于戒烟的尼古丁电子烟：临床药理学视角
Expert Rev Clin Pharmacol. 2025 Apr;18(4):189-196. doi: 10.1080/17512433.2025.2472837. Epub 2025 Mar 7.
4
Immunological Effects of Electronic Cigarette Use: A Review of Current Evidence.电子烟使用的免疫学效应：当前证据综述
Clin Rev Allergy Immunol. 2025 Feb 1;68(1):9. doi: 10.1007/s12016-025-09026-5.
5
Total and unprotonated (freebase) nicotine content in new types of oral 'tobacco-free' nicotine products.新型口服“无烟”尼古丁产品中的总尼古丁含量及未质子化（游离碱）尼古丁含量。
Tob Control. 2024 Nov 14. doi: 10.1136/tc-2024-058914.
6
Examining acute psychopharmacological effects of nicotine vaping versus heated tobacco products in a randomised crossover study of product naïve adult smokers.在一项针对产品无经验成年吸烟者的随机交叉研究中，检查尼古丁蒸气与加热烟草产品的急性精神药理学效应。
Sci Rep. 2023 Dec 19;13(1):22676. doi: 10.1038/s41598-023-49602-3.
7
Evaluating the effects of nicotine concentration on the appeal and nicotine delivery of oral nicotine pouches among rural and Appalachian adults who smoke cigarettes: A randomized cross-over study.评估尼古丁浓度对农村和阿巴拉契亚地区成年吸烟者对口腔尼古丁袋的吸引力和尼古丁传递的影响：一项随机交叉研究。
Addiction. 2024 Mar;119(3):464-475. doi: 10.1111/add.16355. Epub 2023 Nov 14.
8
Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials.尼古丁流量作为调节电子烟中尼古丁释放的有力工具：两项互补随机交叉临床试验方案。
PLoS One. 2023 Sep 21;18(9):e0291786. doi: 10.1371/journal.pone.0291786. eCollection 2023.
9
Nicotine e-cigarettes as a tool for smoking cessation.尼古丁电子烟作为戒烟工具。
Nat Med. 2023 Mar;29(3):520-524. doi: 10.1038/s41591-022-02201-7.
10
Dose-response effects of two nicotine salt formulations on electronic cigarette appeal and sensory attributes.两种尼古丁盐制剂对电子烟吸引力和感官属性的剂量反应效应。
Tob Control. 2023 Jan 2. doi: 10.1136/tc-2022-057553.

本文引用的文献

1
The pH of Smokeless Tobacco Determines Nicotine Buccal Absorption: Results of a Randomized Crossover Trial.无烟烟草的pH值决定尼古丁的颊部吸收：一项随机交叉试验的结果
Clin Pharmacol Ther. 2022 May;111(5):1066-1074. doi: 10.1002/cpt.2493. Epub 2021 Dec 17.
2
Balancing Consideration of the Risks and Benefits of E-Cigarettes.权衡电子烟的风险和益处。
Am J Public Health. 2021 Sep;111(9):1661-1672. doi: 10.2105/AJPH.2021.306416. Epub 2021 Aug 19.
3
Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame.电子尼古丁传送系统（ENDS）的临床药理学：对促进燃烧烟草终结策略中获益与风险的影响。
J Clin Pharmacol. 2021 Aug;61 Suppl 2(Suppl 2):S18-S36. doi: 10.1002/jcph.1915.
4
Characterization of Total and Unprotonated (Free) Nicotine Content of Nicotine Pouch Products.描述尼古丁袋产品中总尼古丁和未质子化（游离）尼古丁的含量。
Nicotine Tob Res. 2021 Aug 18;23(9):1590-1596. doi: 10.1093/ntr/ntab030.
5
Characterization of Nicotine Salts in 23 Electronic Cigarette Refill Liquids.23 种电子烟补充液中尼古丁盐的特性分析。
Nicotine Tob Res. 2020 Jun 12;22(7):1239-1243. doi: 10.1093/ntr/ntz232.
6
Compensatory Puffing With Lower Nicotine Concentration E-liquids Increases Carbonyl Exposure in E-cigarette Aerosols.低尼古丁浓度烟油补偿性大烟雾增加电子烟气溶胶中羰基化合物暴露。
Nicotine Tob Res. 2018 Jul 9;20(8):998-1003. doi: 10.1093/ntr/ntx162.
7
Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users.西南阿拉斯加原住民烟民和非吸烟者接触尼古丁和致癌物质的情况。
Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):934-42. doi: 10.1158/1055-9965.EPI-11-1178. Epub 2012 Apr 6.
8
Nicotine addiction.尼古丁成瘾
N Engl J Med. 2010 Jun 17;362(24):2295-303. doi: 10.1056/NEJMra0809890.
9
Pharmacokinetics and pharmacodynamics of moist snuff in humans.湿鼻烟在人体中的药代动力学和药效学。
Tob Control. 1999 Winter;8(4):387-92. doi: 10.1136/tc.8.4.387.