Polosa R, Emma R, Cibella F, Caruso M, Conte G, Benfatto F, Ferlito S, Gulino A, Malerba M, Caponnetto P
Centre for the Prevention and Treatment of Tobacco Addiction (CPCT), Teaching Hospital Policlinico - V. Emanuele, University of Catania, Catania, Italy Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Italy Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Centre for the Prevention and Treatment of Tobacco Addiction (CPCT), Teaching Hospital Policlinico - V. Emanuele, University of Catania, Catania, Italy, Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Catania, Italy.
Ther Adv Chronic Dis. 2021 Aug 12;12:20406223211035267. doi: 10.1177/20406223211035267. eCollection 2021.
Tobacco smoking impairs mucociliary clearance (MCC) efficiency as shown by prolonged saccharin test transit time (STTT). Avoiding exposure to tobacco smoke from combustible cigarettes may restore MCC function and former smokers have been shown to exhibit similar STTT as never smokers. The impact on STTT of switching from smoking to combustion-free tobacco products such as e-cigarettes (ECs) and heated tobacco products (HTPs) is not known.
We report STTT of exclusive EC and HTP users. Test results were compared with those obtained in current, former, and never smokers.
STTT were obtained from 39 current, 40 former, 40 never smokers, and from 20 EC and 20 HTP users. Comparison of STTT values showed significant difference among the five study groups ( < 0.00001) with current smokers having a median [interquartile range (IQR)] STTT of 13.15 min, which was significantly longer compared with that of all other study groups. In particular, compared with former (7.26 min) and never smokers (7.24 min), exclusive EC users and exclusive HTP users had similar STTT at 7.00 and 8.00 min, respectively.
Former smokers who have switched to exclusive regular use of combustion-free nicotine delivery systems (i.e., ECs and HTPs) exhibit similar saccharin transit time as never and former smokers. This suggests that combustion-free nicotine delivery technologies are unlikely to have detrimental effects on MCC function.
如糖精试验转运时间（STTT）延长所示，吸烟会损害黏液纤毛清除（MCC）效率。避免接触可燃香烟的烟雾可能会恢复MCC功能，并且已表明既往吸烟者的STTT与从不吸烟者相似。从吸烟转向使用电子烟（EC）和加热烟草制品（HTP）等无烟烟草制品对STTT的影响尚不清楚。
我们报告了仅使用EC和HTP者的STTT。将测试结果与当前吸烟者、既往吸烟者和从不吸烟者的结果进行比较。
获得了39名当前吸烟者、40名既往吸烟者、40名从不吸烟者以及20名EC使用者和20名HTP使用者的STTT。STTT值的比较显示五个研究组之间存在显著差异（<0.00001），当前吸烟者的STTT中位数[四分位间距（IQR）]为13.15分钟，与所有其他研究组相比显著更长。特别是，与既往吸烟者（7.26分钟）和从不吸烟者（7.24分钟）相比，仅使用EC者和仅使用HTP者的STTT分别为7.00分钟和8.00分钟，相似。
已转而仅定期使用无烟尼古丁递送系统（即EC和HTP）的既往吸烟者表现出与从不吸烟者和既往吸烟者相似的糖精转运时间。这表明无烟尼古丁递送技术不太可能对MCC功能产生有害影响。
