Hormaeche C E
Immunology. 1979 Jun;37(2):329-32.
Differences in the in vivo net growth rate of Salmonella typhimurium C5 during the first week of infection in different mouse strains are controlled by a single autosomal gene. In lethally irradiated mice repopulated with semi-allogeneic bone marrow, the early net growth rate shows the phenotype of the donor of the bone marrow cell and not the phenotype of the irradiated recipient. Thus, genetically controlled differences in in vivo bacterial net growth rate are a consequence of mechanisms operating in cells which have originated from bone marrow precursors. Natural resistance to S. typhimurium C5 requires, in addition to slow net growth rate, other mechanisms which come into operation at the end of the first week of the infection. These later acting processes are more complex and can not be transferred to susceptible mice using bone marrow cells alone.
鼠伤寒沙门氏菌C5在不同小鼠品系感染第一周内的体内净生长率差异由单个常染色体基因控制。在接受半同种异体骨髓移植的致死性辐照小鼠中，早期净生长率表现为骨髓细胞供体的表型，而非辐照受体的表型。因此，体内细菌净生长率的基因控制差异是源自骨髓前体细胞的细胞中运作机制的结果。对鼠伤寒沙门氏菌C5的天然抗性除了需要缓慢的净生长率外，还需要在感染第一周结束时开始运作的其他机制。这些后期起作用的过程更为复杂，不能仅通过骨髓细胞转移到易感小鼠体内。
