Mastroeni Pietro, Grant Andrew, Restif Olivier, Maskell Duncan
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Nat Rev Microbiol. 2009 Jan;7(1):73-80. doi: 10.1038/nrmicro2034.
The events that determine the dynamics of proliferation, spread and distribution of microbial pathogens within their hosts are surprisingly heterogeneous and poorly understood. We contend that understanding these phenomena at a sophisticated level with the help of mathematical models is a prerequisite for the development of truly novel, targeted preventative measures and drug regimes. We describe here recent studies of Salmonella enterica infections in mice which suggest that bacteria resist the antimicrobial environment inside host cells and spread to new sites, where infection foci develop, and thus avoid local escalation of the adaptive immune response. We further describe implications for our understanding of the pathogenic mechanism inside the host.
决定微生物病原体在其宿主内增殖、传播和分布动态的事件惊人地具有异质性，且了解甚少。我们认为，借助数学模型在复杂层面理解这些现象是开发真正新颖、有针对性的预防措施和药物治疗方案的先决条件。我们在此描述了近期对小鼠肠道沙门氏菌感染的研究，这些研究表明，细菌能抵抗宿主细胞内的抗菌环境，并扩散到新的部位，在那里形成感染灶，从而避免适应性免疫反应在局部升级。我们还进一步阐述了这些研究对我们理解宿主机理的启示。
