Hirst R G, Campbell R
Infect Immun. 1977 Aug;17(2):319-24. doi: 10.1128/iai.17.2.319-324.1977.
Involvement of the mononuclear phagocyte system in the mechanism of resistance to Corynebacterium kutscheri was studied in C57B1/6 and Swiss Lynch mice. A major difference between the two mouse strains was that the phagocytic cells of the livers of C57B1/6 mice destroyed the bacteria with much greater efficiency. There was no evidence of serum factors which might have led to this greater bacterial killing observed in the C57B1/6 mice, and in vivo phagocytosis of C. kutscheri was identical in both mouse strains. Resistance to C. kutscheri could be transferred with spleen and/or bone marrow cells from resistant (Swiss Lynch X C57B1/6) F1 mice to 650-rad irradiated susceptible Swiss Lynch mice. Nonspecific and acquired mechanisms of resistance to C. kutscheri are discussed.
在C57B1/6和瑞士林奇小鼠中研究了单核吞噬细胞系统在抵抗库氏棒状杆菌机制中的作用。这两种小鼠品系之间的一个主要差异是,C57B1/6小鼠肝脏中的吞噬细胞破坏细菌的效率要高得多。没有证据表明血清因子可能导致在C57B1/6小鼠中观察到的更强的细菌杀伤作用,并且两种小鼠品系中库氏棒状杆菌的体内吞噬作用是相同的。对库氏棒状杆菌的抗性可以通过来自抗性(瑞士林奇×C57B1/6)F1小鼠的脾脏和/或骨髓细胞转移到经650拉德辐照的易感瑞士林奇小鼠中。讨论了对库氏棒状杆菌抗性的非特异性和获得性机制。