Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, People's Republic of China.
Department of Otorhinolaryngology Head and Neck Surgery, Changhai Hospital Affiliated with the Second Military Medical University of PLA, Shanghai, China.
Biomed Pharmacother. 2024 Jan;170:115995. doi: 10.1016/j.biopha.2023.115995. Epub 2023 Dec 19.
Iatrogenic laryngotracheal stenosis (iLTS) is a pathological condition characterized by the narrowing of the laryngeal and tracheal structures due to the formation of abnormal scar tissue. The core of iLTS lies in the fibrosis of the laryngotracheal tissue, and recent research has unveiled novel discoveries regarding the underlying mechanisms of fibrosis. This review provides an overview of the recent advancements in understanding the mechanisms of fibrosis in iLTS. It encompasses various aspects, such as immune system dysregulation, changes in the extracellular matrix (ECM), metabolic alterations, and the role of microbial flora. The review also explores the interplay and relationships between these new mechanisms, establishing a theoretical foundation for the development of multi-target therapies and combination therapies for iLTS.
医源性喉气管狭窄（iLTS）是一种病理性疾病，其特征为由于异常瘢痕组织的形成而导致喉和气管结构变窄。iLTS 的核心在于喉气管组织的纤维化，最近的研究揭示了纤维化潜在机制的新发现。本综述概述了对 iLTS 纤维化机制的最新理解进展。它涵盖了许多方面，如免疫系统失调、细胞外基质（ECM）的变化、代谢改变以及微生物菌群的作用。该综述还探讨了这些新机制之间的相互作用和关系，为 iLTS 的多靶点治疗和联合治疗的发展奠定了理论基础。
