Effect of N-aminomethylpiperazine-3,3-diethyl-2,4-pyridinedione on the aggressive behaviour and avoidance training of rats with isolation syndrome.

The article investigates the effect of N-aminomethylpiperazine-3,3-diethyl-2,4-pyridinedione (DKMP), a newly-synthesized compound with a clearly manifested anticonvulsant action, on the aggressive behaviour and on the training for active two-way avoidance by using a shuttle-box. The effects of DKMP were compared with the effects of Diazepam on mouse killing behaviour and avoidance training both of isolated aggressive rats and of rats reared in groups. It was found that DKMP (100 mg/kg, subcutaneously) inhibited the aggressiveness in 88 per cent of the aggressive rats, whereas Diazepam (1 mg/kg, i. p.)--in 75 per cent for 4 hours. DKMP manifested a more substantial positive effect on learning (higher number of avoidances) in the aggressive rats, whereas Diazepam had a better effect on the group-reared rats. Both compounds shortened the latencies of the avoidances of aggressive rats, inducing no changes in the grouped rats. The results obtained show that with respect to the effects studied there is similarity in the pharmacological activities of DKMP and Diazepam, indicating only some not very essential quantitative differences.