Petkov V V, Rousseva S
Methods Find Exp Clin Pharmacol. 1984 Aug;6(8):433-6.
Caffeine at a dose of 40 mg/kg i.p. administered 60 min before testing for aggressive mouse-killing behavior in Wistar rats with isolation syndrome inhibited mouse-killing response in 48 per cent of the aggressive rats. When injected 60 min before two-way active avoidance training caffeine improved learning in grouped rats, did not facilitate it in isolated non-aggressive rats and significantly improved avoidance behavior in isolated aggressive rats. The antiaggressive effect of caffeine is most probably due to its inhibitory action on phosphodiesterase and the resulting increase of brain cAMP, to the provoked increase of brain 5-HT and to its binding to brain benzodiazepine receptors. The positive effect of caffeine on avoidance learning of isolated aggressive rats is likely due to its indirect stimulant action on the brain dopaminergic system.
给患有隔离综合征的Wistar大鼠进行攻击性行为（杀鼠行为）测试前60分钟腹腔注射40毫克/千克剂量的咖啡因，可抑制48%的攻击性大鼠的杀鼠反应。在双向主动回避训练前60分钟注射咖啡因，可改善群居大鼠的学习能力，对隔离的非攻击性大鼠无促进作用，但可显著改善隔离的攻击性大鼠的回避行为。咖啡因的抗攻击作用很可能是由于其对磷酸二酯酶的抑制作用以及由此导致的脑内环磷酸腺苷（cAMP）增加、引发的脑内5-羟色胺（5-HT）增加以及与脑苯二氮䓬受体的结合。咖啡因对隔离的攻击性大鼠回避学习的积极作用可能是由于其对脑多巴胺能系统的间接刺激作用。
