Petkov V V, Vaglenova J
Acta Physiol Pharmacol Bulg. 1986;12(4):36-41.
Male Wistar rats were trained for active two-way avoidance in a shuttle-box apparatus for five consecutive days. Meclofenoxate, in doses of 100 and 300 mg/kg i.p., was applied in two separate groups of rats, 60 min before the beginning of the training. Meclofenoxate (Mf), applied in a dose of 100 mg/kg, slightly improved the avoidance training, whereas in a dose of 300 mg/kg it "deteriorated" learning during the last two training days. Retrospective analysis of the experimental results showed that Mf caused a dose-dependent increase in the percentage of rats who were "poor learners", compared with the percentage of "poor learners" among the controls. On the other hand, the Mf-treated "good learners" manifested an essentially better capacity for avoidance training, compared with the control "good learners". The data obtained suggest that Mf increases the adaptational capacities of rats trained for active avoidance possibly in two different ways: in part of the animals it causes improvement of the conditioned reflex activity, in another part of the animals it increases their resistance to the stressogenic stimuli used during such a training.
将雄性Wistar大鼠置于穿梭箱装置中连续5天进行主动双向回避训练。在训练开始前60分钟，将剂量为100毫克/千克和300毫克/千克的氯酯醒分别应用于两组不同的大鼠。剂量为100毫克/千克的氯酯醒略微改善了回避训练，而剂量为300毫克/千克的氯酯醒在最后两天的训练中“恶化”了学习效果。对实验结果的回顾性分析表明，与对照组中“学习能力差”的大鼠百分比相比，氯酯醒使“学习能力差”的大鼠百分比呈剂量依赖性增加。另一方面，与对照“学习能力好”的大鼠相比，接受氯酯醒治疗的“学习能力好”的大鼠在回避训练中表现出明显更好的能力。获得的数据表明，氯酯醒可能通过两种不同方式提高接受主动回避训练大鼠的适应能力：在部分动物中，它会改善条件反射活动，在另一部分动物中，它会增加它们对这种训练期间使用的应激源刺激的抵抗力。
