Atanassova E, Kortezova N, Papasova M
Acta Physiol Pharmacol Bulg. 1986;12(3):20-6.
Experiments were carried out on seven breedless dogs with chronically implanted electrodes in the stomach. The effect of hexamethonium (in doses of 0.2, 0.3, 0.5, 1, 2, 3, 5, 7 and 10 mg/kg, i. v.) on the migrating myoelectrical complex (MMC) was studied before and after transthoracic vagotomy. Injected on the background of the first MMC phase, hexamethonium in doses of up to 2 mg/kg induces the appearance of spike potentials (SP). Applied on the background of spike activity, hexamethonium induces the appearance of spike activity of the type of the 3rd MMC phase. In a dose exceeding 2 mg/kg, introduced during SP activity, hexamethonium interrupts for different periods of time the SP generation and shortens the duration of the active MMC phases. On the background of increased spike activity characteristic of the stomach after vagotomy, 3 mg/kg hexamethonium have almost no effect on the electrical activity, whereas 10 mg/kg only reduce the percentage of slow waves accompanied by SP. It is probably that after vagotomy the excitability of the intrinsic nerve cells is increased, therefore even the high doses of the ganglionic blocker hexamethonium cannot inhibit entirely the active phases of MMC.
对7只在胃内长期植入电极的无品种犬进行了实验。研究了六甲铵（静脉注射剂量为0.2、0.3、0.5、1、2、3、5、7和10mg/kg）在经胸迷走神经切断术前和术后对移行性肌电复合波（MMC）的影响。在MMC第一相的背景下注射，剂量高达2mg/kg的六甲铵会诱导出现锋电位（SP）。在锋电位活动的背景下应用，六甲铵会诱导出现第三相MMC类型的锋电位活动。在SP活动期间注射超过2mg/kg的剂量，六甲铵会在不同时间段中断SP的产生，并缩短活跃MMC相的持续时间。在迷走神经切断术后胃所特有的锋电位活动增加的背景下，3mg/kg的六甲铵对电活动几乎没有影响，而10mg/kg仅降低伴有SP的慢波百分比。可能是迷走神经切断术后内在神经细胞的兴奋性增加，因此即使是高剂量的神经节阻滞剂六甲铵也不能完全抑制MMC的活跃相。
