Colorectal Dis. 2024 Feb;26(2):371-379. doi: 10.1111/codi.16822. Epub 2023 Dec 20.
The watch-and-wait approach is increasingly being used in the management of rectal cancer as many patients achieve a clinical complete response after neoadjuvant treatment This national, multicentre, retrospective cohort study aims to understand the use of the watch-and-wait approach in the management of rectal cancer in Aotearoa New Zealand and its associated outcomes.
This retrospective cohort study will include patients aged 18 years and over with biopsy proven rectal adenocarcinoma diagnosed between January 2015 and December 2022 who have a clinical complete response following neoadjuvant treatment (including short-course radiotherapy, long-course chemoradiotherapy or total neoadjuvant treatment) and have been managed with a watch-and-wait approach. Data will be collected from centres that manage rectal cancer in Aotearoa New Zealand with the eligible population being identified using data linkage with the National Cancer Registry.
This multicentre, national cohort study will investigate the use of the watch-and-wait strategy for rectal cancer in Aotearoa New Zealand. Through novel data linkage approaches, these data and methods will lay the foundation for a future prospective registry and outcome-tracking initiative.
随着许多患者在新辅助治疗后达到临床完全缓解，观望等待策略在直肠癌的治疗中越来越多地被采用。这项全国性、多中心、回顾性队列研究旨在了解新西兰在直肠癌治疗中观望等待策略的使用情况及其相关结果。
这项回顾性队列研究将包括年龄在 18 岁及以上、经活检证实的直肠腺癌患者，这些患者在新辅助治疗（包括短程放疗、长程放化疗或全新辅助治疗）后有临床完全缓解，且采用观望等待策略进行治疗。数据将从新西兰管理直肠癌的中心收集，通过与国家癌症登记处的数据链接来确定符合条件的人群。
这项多中心、全国性队列研究将调查新西兰采用观望等待策略治疗直肠癌的情况。通过新颖的数据链接方法，这些数据和方法将为未来的前瞻性登记和结果跟踪倡议奠定基础。
