Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
Clinical Research Center for Medical Imaging in Hubei Province, 1277 Jiefang Avenue, Wuhan 430022, China.
ACS Biomater Sci Eng. 2024 Jan 8;10(1):298-312. doi: 10.1021/acsbiomaterials.3c01232. Epub 2023 Dec 20.
Sonodynamic therapy is an emerging noninvasive tumor treatment method that utilizes ultrasound to stimulate sonosensitizers to produce a large amount of reactive oxygen species, inducing tumor cell death. Though sonodynamic therapy has very promising prospects in cancer treatment, the application of early organic sonosensitizers has been limited in efficacy due to the high blood clearance-rate, poor water solubility, and low stability. Inorganic sonosensitizers have thus been developed, among which piezoelectric semiconductor materials have received increasing attention in sonodynamic therapy due to their piezoelectric properties and strong stability. In this review, we summarized the designs, principles, modification strategies, and applications of several commonly used piezoelectric materials in sonodynamic therapy and prospected the future clinical applications for piezoelectric semiconductor materials in sonodynamic therapy.
声动力学疗法是一种新兴的无创肿瘤治疗方法，利用超声波刺激声敏剂产生大量的活性氧，诱导肿瘤细胞死亡。尽管声动力学疗法在癌症治疗方面具有非常广阔的前景，但由于血液清除率高、水溶性差和稳定性低，早期有机声敏剂的应用在疗效上受到限制。因此，人们开发了无机声敏剂，其中压电半导体材料因其压电特性和强稳定性而在声动力学治疗中受到越来越多的关注。在本文中，我们总结了几种常用压电材料在声动力学治疗中的设计、原理、修饰策略及应用，并对压电半导体材料在声动力学治疗中的未来临床应用进行了展望。
