Shojania A M, Meilleur G, Alvi A W
Am J Hematol. 1987 Feb;24(2):207-14. doi: 10.1002/ajh.2830240212.
A 41-year-old man with posthepatic liver cirrhosis and bleeding tendency was found to have a circulating anticoagulant with potent antithrombin activity. The thrombin time of the patient's purified fibrinogen was normal. This anticoagulant was residing in the patient's IgG fraction, and his IgG fraction could prolong the thrombin time of purified fibrinogen, suggesting that this circulating anticoagulant was an antibody. No heparin was detected in the patient's plasma. However, the antithrombin activity of this anticoagulant could be neutralized by toluidine blue or methylene blue ex vivo.
一名患有肝后性肝硬化和出血倾向的41岁男性被发现有一种具有强效抗凝血酶活性的循环抗凝物质。该患者纯化纤维蛋白原的凝血酶时间正常。这种抗凝物质存在于患者的IgG组分中，其IgG组分可延长纯化纤维蛋白原的凝血酶时间，提示这种循环抗凝物质是一种抗体。患者血浆中未检测到肝素。然而，这种抗凝物质的抗凝血酶活性在体外可被甲苯胺蓝或亚甲蓝中和。
