Manjit Manjit, Kumar Manish, Kumar Krishan, Dhondale Madhukiran R, Jha Abhishek, Bharti Kanchan, Rain Zinnu, Prakash Pradyot, Mishra Brahmeshwar
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, (BHU), Varanasi, Uttar Pradesh, 221005, India.
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Ther Deliv. 2023 Dec 21. doi: 10.4155/tde-2023-0083.
Design of moxifloxacin and ornidazole co-loaded polycaprolactone and gelatin nanofiber dressing for diabetic wounds. The composite nanofibers were prepared using electrospinning technique and characterized for drug release, antibacterial activity, laser doppler and wound healing. The optimized nanofiber demonstrated an interconnected bead free nanofiber with average diameter <200 nm. The drug release & antimicrobial studies revealed that optimized nanofiber provided drug release for >120 h, thereby inhibiting growth of and . An wound closure study on diabetic rats found that optimized nanofiber group had a significantly higher wound closure rate than marketed formulation. The nanofiber provided prolonged drug release and accelerated wound healing, making it a promising candidate for diabetic wound care.
用于糖尿病伤口的莫西沙星和奥硝唑共载聚己内酯和明胶纳米纤维敷料的设计。采用静电纺丝技术制备复合纳米纤维，并对其药物释放、抗菌活性、激光多普勒和伤口愈合情况进行表征。优化后的纳米纤维呈现出无珠粒且相互连通的纳米纤维，平均直径小于200纳米。药物释放和抗菌研究表明，优化后的纳米纤维能实现超过120小时的药物释放，从而抑制……的生长。对糖尿病大鼠的伤口闭合研究发现，优化后的纳米纤维组的伤口闭合率明显高于市售制剂。该纳米纤维提供了长效药物释放并加速了伤口愈合，使其成为糖尿病伤口护理的一个有前景的候选材料。 （原文中“thereby inhibiting growth of and.”部分缺失具体内容）
