Fabrication of dual drug-loaded polycaprolactone-gelatin composite nanofibers for full thickness diabetic wound healing.

Design of moxifloxacin and ornidazole co-loaded polycaprolactone and gelatin nanofiber dressing for diabetic wounds. The composite nanofibers were prepared using electrospinning technique and characterized for drug release, antibacterial activity, laser doppler and wound healing. The optimized nanofiber demonstrated an interconnected bead free nanofiber with average diameter <200 nm. The drug release & antimicrobial studies revealed that optimized nanofiber provided drug release for >120 h, thereby inhibiting growth of and . An wound closure study on diabetic rats found that optimized nanofiber group had a significantly higher wound closure rate than marketed formulation. The nanofiber provided prolonged drug release and accelerated wound healing, making it a promising candidate for diabetic wound care.