Abant Izzet Baysal University, Department of Internal Medicine, Bolu, Turkey.
Abant Izzet Baysal University, Department of Medical Biochemistry, Bolu, Turkey.
Malawi Med J. 2023 Mar;35(1):15-21. doi: 10.4314/mmj.v35i1.4.
Prognostic nutritional index (PNI) is a novel inflammation marker that useful in predicting prognosis of certain conditions. We aimed to study PNI of the outpatient and inpatient subjects with established Covid-19 and also aimed to compare PNI of deceased and survived Covid-19 patients.
The patients with Covid-19 whom presented to outpatient or inpatient clinics of Abant Izzet Baysal University Hospital were enrolled to the study. PNI levels of the inpatients and outpatients, deceased and survived were compared. PNI values of deceased and survived in inpatients were also compared.
Study population was consisted of 4419 subjects (2907 outpatients and 1512 inpatients). PNI of the inpatient (41.55 (36.42-47.1)) group was significantly lower than the PNI of the outpatient (51.95 (47.95-55.75)) subjects (p<0.001). The sensitivity and specificity of PNI (≤46.2 level) in determination of requirement inpatient treatment were 71.2% and 83.5%, respectively. PNI of the deceased patients (37(33.39-40.86)) was lower than the PNI of the survivors (50.45(45.6-54.65)), (p<0.001). The sensitivity and specificity of PNI at ≤44.55 level in determining mortality were 89.22% and 78.87%, respectively.
We suggest that PNI could serve as a reliable prognostic index in covid-19 patients. Reduced level of PNI should alert physicians since it is associated with need for hospitalization and mortality in this population.
预后营养指数（PNI）是一种新的炎症标志物，可用于预测某些疾病的预后。我们旨在研究已确诊的 COVID-19 门诊和住院患者的 PNI，并比较死亡和存活的 COVID-19 患者的 PNI。
将就诊于阿班特·伊泽特·贝萨尔大学医院门诊或住院病房的 COVID-19 患者纳入研究。比较住院和门诊患者、死亡和存活患者的 PNI 水平。还比较了住院患者中死亡和存活患者的 PNI 值。
研究人群由 4419 名患者（2907 名门诊患者和 1512 名住院患者）组成。住院患者（41.55（36.42-47.1））组的 PNI 明显低于门诊患者（51.95（47.95-55.75））（p<0.001）。PNI（≤46.2 水平）用于确定住院治疗需求的灵敏度和特异性分别为 71.2%和 83.5%。死亡患者的 PNI（37（33.39-40.86））低于存活患者的 PNI（50.45（45.6-54.65）），（p<0.001）。PNI 在≤44.55 水平预测死亡率的灵敏度和特异性分别为 89.22%和 78.87%。
我们认为 PNI 可以作为 COVID-19 患者的可靠预后指标。该人群中，PNI 水平降低应引起医生警惕，因为它与住院和死亡相关。
