PS - 5，一种新型β - 内酰胺抗生素。III. 对β - 内酰胺酶的协同作用和抑制活性。

PS-5, a new beta-lactam antibiotic. III. Synergistic effects and inhibitory activity against a beta-lactamase.

作者信息

Okamura K, Sakamoto M, Fukagawa Y, Ishikura T, Lein J

出版信息

J Antibiot (Tokyo). 1979 Apr;32(4):280-6. doi: 10.7164/antibiotics.32.280.

DOI:10.7164/antibiotics.32.280

Abstract

PS-5 was shown to have synergistic activity in combination with other beta-lactam antibiotics and it markedly decreased the minimum inhibitory concentration values of ampicillin or cephaloridine with a beta-lactamase-producing Proteus vulgaris strain on agar plates. The synergistic activities were also shown in bactericidal activity in liquid medium. PS-5 was shown to be inhibitory against an extracted beta-lactamase of P. volgaris.

摘要

PS - 5与其他β-内酰胺类抗生素联合使用时具有协同活性，并且在琼脂平板上能显著降低氨苄青霉素或头孢菌素对产β-内酰胺酶的普通变形杆菌菌株的最低抑菌浓度值。在液体培养基中的杀菌活性方面也表现出协同活性。PS - 5对普通变形杆菌提取的β-内酰胺酶具有抑制作用。