阿莫西林与克拉维酸联合对耐氨苄西林菌株的抗菌活性。
Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.
作者信息
Matsuura M, Nakazawa H, Hashimoto T, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1980 Jun;17(6):908-11. doi: 10.1128/AAC.17.6.908.
Abstract
Strains of bacteria resistant to beta-lactam antibiotics have been increasing in number and are becoming troublesome in clinical medicine. The in vitro antibacterial activity of amoxicillin combined with clavulanic acid was determined on selected ampicillin-resistant clinical isolates. Synergistic effects were produced by amoxicillin with clavulanic acid against ampicillin-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, and Bacteroides fragilis. Inhibition of the beta-lactamases produced by the ampicillin-resistant strains was confirmed, especially against the penicillinases mediated by the R factor and the cephalosporinases produced by P.vulgaris and B. fragilis. The inhibitory effect of clavulanic acid against beta-lactamases was irreversible because of the high affinity of clavulanic acid to the enzymes.
摘要
对β-内酰胺类抗生素耐药的细菌菌株数量一直在增加，并且在临床医学中变得棘手。对选定的耐氨苄西林临床分离株测定了阿莫西林与克拉维酸联合的体外抗菌活性。阿莫西林与克拉维酸对耐氨苄西林的金黄色葡萄球菌、大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、普通变形杆菌和脆弱拟杆菌菌株产生协同作用。证实了克拉维酸对耐氨苄西林菌株产生的β-内酰胺酶有抑制作用，尤其是对由R因子介导的青霉素酶以及由普通变形杆菌和脆弱拟杆菌产生的头孢菌素酶。由于克拉维酸对这些酶具有高亲和力，其对β-内酰胺酶的抑制作用是不可逆的。
相似文献
1
Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.阿莫西林与克拉维酸联合对耐氨苄西林菌株的抗菌活性。
Antimicrob Agents Chemother. 1980 Jun;17(6):908-11. doi: 10.1128/AAC.17.6.908.
2
Antibacterial activities of amoxicillin alone and in combination with clavulanic acid correlated with beta-lactamase production.阿莫西林单独及与克拉维酸联合使用时的抗菌活性与β-内酰胺酶的产生相关。
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1991 Aug;24(3):272-80.
3
In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.
Infection. 1980;8(3):104-6. doi: 10.1007/BF01641472.
4
The in vitro activity of amoxycillin with clavulanic acid against clinically significant bacteria. A multicentre study.
S Afr Med J. 1982 Jul 28;62(5 Spec No):5A-8A.
5
In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b.阿莫西林与克拉维酸对耐氨苄西林的b型流感嗜血杆菌的体外及体内协同作用
Antimicrob Agents Chemother. 1981 Jun;19(6):993-6. doi: 10.1128/AAC.19.6.993.
6
In-vitro evaluation of ampicillin/brobactam and comparison with other beta-lactam antibiotics.氨苄西林/布罗巴坦的体外评价及与其他β-内酰胺类抗生素的比较。
J Antimicrob Chemother. 1991 Jan;27(1):29-40. doi: 10.1093/jac/27.1.29.
7
Augmentin: laboratory studies.阿莫西林克拉维酸钾：实验室研究。
Scott Med J. 1982;27 Spec No.:S21-3. doi: 10.1177/00369330820270S105.
8
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam.四种β-内酰胺酶抑制剂：BRL42715、克拉维酸、舒巴坦和他唑巴坦的体外评估。
J Antimicrob Chemother. 1993 Sep;32(3):421-9. doi: 10.1093/jac/32.3.421.
9
Synergistic antibacterial activity of clavulanic acid and amoxicillin against beta-lactamase-producing strains of Haemophilus ducreyi.克拉维酸与阿莫西林对产β-内酰胺酶的杜克雷嗜血杆菌菌株的协同抗菌活性。
Antimicrob Agents Chemother. 1981 Jul;20(1):144-5. doi: 10.1128/AAC.20.1.144.
10
[Combined antibacterial activity of clavulanic acid with amoxicillin and ampicillin against Gram-negative strains].
Boll Ist Sieroter Milan. 1984;63(5):447-52.
引用本文的文献
1
the impact of stakeholder decision-making on antimicrobial resistance evolution.利益相关者决策对抗菌药物耐药性演变的影响。
Microbiology (Reading). 2025 Feb;171(2). doi: 10.1099/mic.0.001534.
2
Cinnamaldehyde targets SarA to enhance β-lactam antibiotic activity against methicillin-resistant .肉桂醛作用于SarA以增强β-内酰胺类抗生素对耐甲氧西林菌的活性。
mLife. 2024 Jun 14;3(2):291-306. doi: 10.1002/mlf2.12121. eCollection 2024 Jun.
3
State of the Art in the Antibacterial and Antiviral Applications of Carbon-Based Polymeric Nanocomposites.碳基聚合物纳米复合材料在抗菌和抗病毒应用方面的最新进展。
Int J Mol Sci. 2021 Sep 29;22(19):10511. doi: 10.3390/ijms221910511.
4
[Not Available].[无可用内容]
EMC Pediatr. 2001;36(4):1-10. doi: 10.1016/S1245-1789(01)72028-8. Epub 2012 Sep 14.
5
Multitarget Approaches against Multiresistant Superbugs.针对多重耐药超级细菌的多靶点方法。
ACS Infect Dis. 2020 Jun 12;6(6):1346-1365. doi: 10.1021/acsinfecdis.0c00001. Epub 2020 Mar 19.
6
In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.在体内对一株棒状链霉菌β-内酰胺酶相关蛋白进行功能分析，该蛋白对克拉维酸生物合成至关重要。
PLoS One. 2019 Apr 23;14(4):e0215960. doi: 10.1371/journal.pone.0215960. eCollection 2019.
7
Is the standard dose of amoxicillin-clavulanic acid sufficient?阿莫西林-克拉维酸的标准剂量足够吗？
BMC Pharmacol Toxicol. 2014 Jul 21;15:38. doi: 10.1186/2050-6511-15-38.
8
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.分子网络的结构与动态：药物发现的新范例：全面综述。
Pharmacol Ther. 2013 Jun;138(3):333-408. doi: 10.1016/j.pharmthera.2013.01.016. Epub 2013 Feb 4.
9
Mechanisms of drug combinations: interaction and network perspectives.药物组合的机制：相互作用与网络视角
Nat Rev Drug Discov. 2009 Feb;8(2):111-28. doi: 10.1038/nrd2683.
10
Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid.阿莫西林与克拉维酸联合治疗尿路感染
Antimicrob Agents Chemother. 1982 Oct;22(4):672-7. doi: 10.1128/AAC.22.4.672.
本文引用的文献
1
Demonstration of R factors from Pseudomonas aeruginosa.铜绿假单胞菌R因子的证明。
Antimicrob Agents Chemother. 1974 Jun;5(6):547-52. doi: 10.1128/AAC.5.6.547.
2
The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.大肠杆菌中由可传递R因子介导的青霉素β-内酰胺酶的纯化及特性
J Biochem. 1969 Jul;66(1):11-20. doi: 10.1093/oxfordjournals.jbchem.a129111.
3
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.头孢呋辛，一种新型头孢菌素抗生素：体外活性
Antimicrob Agents Chemother. 1976 Mar;9(3):511-9. doi: 10.1128/AAC.9.3.511.
4
Naturally-occurring beta-lactamase inhibitors with antibacterial activity.
J Antibiot (Tokyo). 1976 Jun;29(6):668-9. doi: 10.7164/antibiotics.29.668.
5
Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.克拉维酸：一种来自棒状链霉菌的β-内酰胺酶抑制性β-内酰胺类抗生素。
Antimicrob Agents Chemother. 1977 May;11(5):852-7. doi: 10.1128/AAC.11.5.852.
6
Antimicrobial evaluation of cefoxitin: a new semisynthetic cephamycin. Comparative studies with cefazolin and cefalotin.头孢西丁的抗菌评估：一种新型半合成头孢霉素。与头孢唑林和头孢噻吩的对比研究。
Arzneimittelforschung. 1977;27(1):89-93.
7
Sodium clavulanate potentiation of cephalosporin activity against clinical isolates of cephalothin-resistant Klebsiella pneumoniae.克拉维酸钠对头孢菌素抗临床分离的耐头孢噻吩肺炎克雷伯菌活性的增强作用。
Antimicrob Agents Chemother. 1978 Jul;14(1):118-25. doi: 10.1128/AAC.14.1.118.
8
CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization.CP-45899，一种可扩展β-内酰胺类抗菌谱的β-内酰胺酶抑制剂：初步细菌学特征
Antimicrob Agents Chemother. 1978 Sep;14(3):414-9. doi: 10.1128/AAC.14.3.414.
9
Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli.克拉维酸与替卡西林联合对耐替卡西林革兰氏阴性杆菌的活性
Antimicrob Agents Chemother. 1978 Aug;14(2):224-7. doi: 10.1128/AAC.14.2.224.
10
Biochemical properties of a penicillin beta-lactamase mediated by R factor from Bordetella bronchiseptica.支气管败血波氏杆菌R因子介导的青霉素β-内酰胺酶的生化特性
Antimicrob Agents Chemother. 1975 Sep;8(3):238-42. doi: 10.1128/AAC.8.3.238.
Zotero 插件