Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, China.
Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
High Alt Med Biol. 2023 Dec;24(4):312-320. doi: 10.1089/ham.2022.0099.
Guo, Hai, Linjie Cheng, Dilihumaier Duolikun, and Qiaoling Yao. Aerobic exercise training under normobaric hypoxic conditions to improve glucose and lipid metabolism in overweight and obese individuals: a systematic review and meta-analysis. 24:312-320, 2023. Obesity is a critical public health issue around the world, reaching epidemic proportions in some countries. However, only a few studies have examined the effects of hypoxic training on metabolic parameters in an obese population. This systematic review and meta-analysis aimed to determine the effects of aerobic exercise training under normobaric hypoxic conditions versus normoxic training in improving glucose and lipid metabolism in obese individuals. A systematic search of PubMed, EMBASE, Web of Science, and Wan Fang databases (up to August 2021) was performed to identify randomized controlled trials (RCTs) of overweight or obese human subjects eligible for inclusion. Main study endpoints were changes in body mass index (BMI), waist/hip (W/H) ratio, leptin, blood glucose and insulin levels, as well as blood lipids between hypoxic and normoxic conditioning. Fourteen RCTs with a total of 413 subjects qualified for inclusion. Pooled analyses revealed that BMI ( = 0.38), W/H ratio ( = 0), blood glucose ( = 0.01), and triglyceride ( = -2.27) were not significantly different between aerobic exercise training under hypoxic and normoxic conditions. However, significant differences were found in heart rate at rest ( = -4.50) between aerobic exercise training under hypoxic versus normoxic conditions. In conclusion, no significant benefits were noted in aerobic exercise training under hypoxic conditions over normoxic conditions in overweight or obese individuals. However, the maximum training heart rate mm was significantly higher under hypoxic conditions than under normoxic conditions. Future studies with larger samples controlling for exercise-related parameters, and addressing the potential modifying effects of level of hypoxia, sex, or age on the role of hypoxic exercise training are warranted. PROSPERO registration number: CRD42020221680.
郭海、程林洁、迪利胡玛尔·都力坤和姚乔玲。常压低氧环境下的有氧运动训练对超重和肥胖人群糖脂代谢的影响：系统评价和荟萃分析。24:312-320，2023。肥胖是全球一个严重的公共卫生问题，在一些国家已达到流行程度。然而，只有少数研究检查了低氧训练对肥胖人群代谢参数的影响。本系统评价和荟萃分析旨在确定常压低氧环境下的有氧运动训练与常氧训练对改善肥胖个体糖脂代谢的影响。系统检索 PubMed、EMBASE、Web of Science 和万方数据库（截至 2021 年 8 月），以确定符合纳入标准的超重或肥胖人类受试者的随机对照试验（RCT）。主要研究终点是低氧和常氧条件下体重指数（BMI）、腰臀比（W/H）、瘦素、血糖和胰岛素水平以及血脂的变化。共有 14 项 RCT 符合纳入标准，共纳入 413 名受试者。汇总分析显示，BMI（ = 0.38）、W/H 比（ = 0）、血糖（ = 0.01）和甘油三酯（ = -2.27）在低氧和常氧运动训练之间无显著差异。然而，在低氧与常氧运动训练之间，静息时心率有显著差异（ = -4.50）。综上所述，在超重或肥胖个体中，低氧环境下的有氧运动训练与常氧条件下的有氧运动训练相比，没有显著的益处。然而，低氧条件下的最大训练心率明显高于常氧条件。需要进一步开展研究，纳入更大的样本量，控制运动相关参数，并探讨低氧运动训练对潜在的修饰作用，如缺氧水平、性别或年龄对低氧运动训练作用的影响。PROSPERO 注册号：CRD42020221680。
