人类特异性神经元线粒体和兴奋性的翻译调控。

Human-specific translational control of neuronal mitochondria and excitability.

机构信息

Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.

出版信息

Neuron. 2023 Dec 20;111(24):3901-3903. doi: 10.1016/j.neuron.2023.10.031.

DOI:10.1016/j.neuron.2023.10.031

Abstract

How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al. reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs. These findings suggest that FMRP-mediated translation adapts mitochondria to excitability energy demands.

摘要

人类特有的大脑生物能量学和兴奋性是如何联系在一起的？在本期《神经元》杂志中，Shen 等人揭示了 RACK1 mRNA 和 FMRP 之间的一种人类特有的相互作用。降低 RACK1 可模拟依赖 FMRP 的兴奋性和线粒体表型，而线粒体保护药物可逆转这种表型。这些发现表明，FMRP 介导的翻译使线粒体适应兴奋性的能量需求。