裂叶澳洲茄胺 A-L，植物内生真菌 Austalide 的倍半萜类化合物
Diaporaustalides A-L, Austalide Meroterpenoids from a Plant Endophytic sp.
机构信息
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
出版信息
J Nat Prod. 2024 Jan 26;87(1):141-151. doi: 10.1021/acs.jnatprod.3c00986. Epub 2023 Dec 21.
Twelve new austalide meroterpenoids (-) were isolated from the endophytic fungus sp. XC1211. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of compounds , , , and were established by single-crystal X-ray diffraction, whereas those for the others were established by experimental electronic circular dichroism (ECD) data analysis. Compounds - represent a rare class of austalides with a 24α-CH. Compounds and demonstrated potent proliferation inhibitory effects against LPS-induced B cells with IC values of 6.7 (SI = 3.6) and 3.8 (SI > 13) μM, respectively. Compounds and decreased the secretion of IL-6 in LPS-induced B cells in a dose-dependent manner.
从内生真菌 sp. XC1211 中分离得到 12 种新型的 austalide 倍半萜 (-)。通过广泛的光谱分析阐明了它们的结构。通过单晶 X 射线衍射确定了化合物,,, 和 的绝对构型，而其他化合物的绝对构型则通过实验电子圆二色谱 (ECD)数据分析确定。化合物 - 代表了一类罕见的具有 24α-CH 的 austalide。化合物 和 对 LPS 诱导的 B 细胞的增殖抑制作用具有很强的抑制活性，IC 值分别为 6.7（SI = 3.6）和 3.8（SI > 13）μM。化合物 和 以剂量依赖的方式降低 LPS 诱导的 B 细胞中 IL-6 的分泌。
Zotero 插件