Department of Medicine for Orthopedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Department of Pathophysiology for Locomotive Diseases, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sci Rep. 2023 Dec 20;13(1):22805. doi: 10.1038/s41598-023-49868-7.
We reported that the full-length width of medial tibial osteophytes comprising cartilage and bone parts correlates with medial meniscus extrusion (MME) in early-stage knee osteoarthritis (OA). However, no data exist on the prevalence of MME and its relationship with osteophytes in the elderly population. 1191 elderly individuals (females 57%; 72.9 years old on average) in the Bunkyo Health Study underwent standing plain radiograph and proton density-weighted MRI on knee joints. MRI-detected OA changes were evaluated according to the Whole-Organ Magnetic Resonance Imaging Score. A new method of assessing the cartilage and bone parts of osteophytes was developed using pseudo-coloring images of proton density-weighted fat-suppressed MRI. Most subjects showed Kellgren-Lawrence grade 1 or 2 radiographic medial knee OA (88.1%), MME (98.7%, 3.90 ± 2.01 mm), and medial tibial osteophytes (99.3%, 3.27 ± 1.50 mm). Regarding OA changes, MME was closely associated with the full-length width of medial tibial osteophytes (β = 1.114; 95% CI 1.069-1.159; p < 0.001) in line with osteophyte width (intraclass correlation coefficient, 0.804; 95% CI 0.783-0.823). Our data revealed that MME and medial tibial osteophytes are observed in the elderly and demonstrate that the degree of MME is consistent with the full-length width of medial tibial osteophytes, suggesting that osteophytes might be implicated in MME.
我们曾报道称，包含软骨和骨部分的整个内侧胫骨骨赘的全长宽度与早期膝关节骨关节炎（OA）中的内侧半月板突出（MME）相关。然而，在老年人群中，尚没有关于 MME 的患病率及其与骨赘之间关系的数据。在文京健康研究中，1191 名老年人（女性占 57%；平均年龄为 72.9 岁）接受了膝关节站立位普通 X 线片和质子密度加权 MRI 检查。根据全器官磁共振成像评分（Whole-Organ Magnetic Resonance Imaging Score）评估 MRI 检测到的 OA 改变。使用质子密度加权脂肪抑制 MRI 的伪彩图像开发了一种评估骨赘软骨和骨部分的新方法。大多数患者显示出 Kellgren-Lawrence 分级 1 或 2 的内侧膝关节放射学 OA（88.1%）、MME（98.7%，3.90±2.01mm）和内侧胫骨骨赘（99.3%，3.27±1.50mm）。关于 OA 改变，MME 与内侧胫骨骨赘的全长宽度密切相关（β=1.114；95%置信区间 1.069-1.159；p<0.001），与骨赘宽度一致（组内相关系数，0.804；95%置信区间 0.783-0.823）。我们的数据显示，MME 和内侧胫骨骨赘在老年人中均可见，并且表明 MME 的程度与内侧胫骨骨赘的全长宽度一致，这提示骨赘可能与 MME 有关。
