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A STEP ahead for CAR-T cell therapy of large B cell lymphoma: understanding the molecular determinants of resistance.

作者信息

Mouhssine Samir, Maher Nawar, Gaidano Gianluca

机构信息

Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.

Division of Hematology, Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy.

出版信息

Transl Cancer Res. 2023 Nov 30;12(11):2970-2975. doi: 10.21037/tcr-23-1396. Epub 2023 Nov 17.

DOI:10.21037/tcr-23-1396
PMID:38130313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10731332/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10731332/2e6bd45f28ab/tcr-12-11-2970-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10731332/2e6bd45f28ab/tcr-12-11-2970-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10731332/2e6bd45f28ab/tcr-12-11-2970-f1.jpg

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本文引用的文献

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Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms-Updated Classification and New Concepts.《世界卫生组织血液淋巴系统肿瘤分类第5版——更新后的分类与新概念》中的大B细胞淋巴瘤
Cancers (Basel). 2023 Apr 13;15(8):2285. doi: 10.3390/cancers15082285.
2
Liquid biopsy in hematological malignancies: current and future applications.血液系统恶性肿瘤中的液体活检：当前及未来应用
Front Oncol. 2023 Apr 20;13:1164517. doi: 10.3389/fonc.2023.1164517. eCollection 2023.
3
CAR T Cell Therapy: A Versatile Living Drug.
嵌合抗原受体 T 细胞疗法：一种多功能活体药物。
Int J Mol Sci. 2023 Mar 27;24(7):6300. doi: 10.3390/ijms24076300.
4
A tour de force provides novel insights into CD19-CAR T cell resistance mechanisms.这项研究成果深入探讨了 CD19-CAR T 细胞耐药的机制，让人眼前一亮。
Cell Rep Med. 2023 Feb 21;4(2):100949. doi: 10.1016/j.xcrm.2023.100949.
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Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas.针对大 B 细胞淋巴瘤中 CD19 的工程 T 细胞疗法的耐药性决定因素。
Cancer Cell. 2023 Jan 9;41(1):210-225.e5. doi: 10.1016/j.ccell.2022.12.005. Epub 2022 Dec 29.
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Role of CD19 Chimeric Antigen Receptor T Cells in Second-Line Large B Cell Lymphoma: Lessons from Phase 3 Trials. An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.嵌合抗原受体 T 细胞 CD19 在二线大 B 细胞淋巴瘤中的作用：来自 3 期临床试验的经验教训。美国移植和细胞治疗学会专家小组意见。
Transplant Cell Ther. 2022 Sep;28(9):546-559. doi: 10.1016/j.jtct.2022.06.019. Epub 2022 Jun 26.
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Lancet. 2020 Sep 19;396(10254):839-852. doi: 10.1016/S0140-6736(20)31366-0. Epub 2020 Sep 1.
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Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.使用肿瘤标志物连续动态分析进行个体化预后预测。
Cell. 2019 Jul 25;178(3):699-713.e19. doi: 10.1016/j.cell.2019.06.011. Epub 2019 Jul 4.
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CAR T-cell therapy: Full speed ahead.嵌合抗原受体 T 细胞疗法：全速前进。
Hematol Oncol. 2019 Jun;37 Suppl 1:95-100. doi: 10.1002/hon.2591.