Convolutional neural network (CNN)-based deep learning algorithms have been widely used in recent years for automatic skin lesion segmentation. However, the limited receptive fields of convolutional architectures hinder their ability to effectively model dependencies between different image ranges. The transformer is often employed in conjunction with CNN to extract both global and local information from images, as it excels at capturing long-range dependencies. However, this method cannot accurately segment skin lesions with blurred boundaries. To overcome this difficulty, we proposed ETU-Net.ETU-Net, a novel multi-scale architecture, combines edge enhancement, CNN, and transformer. We introduce the concept of edge detection operators into difference convolution, resulting in the design of the edge enhanced convolution block (EC block) and the local transformer block (LT block), which emphasize edge features. To capture the semantic information contained in local features, we propose the multi-scale local attention block (MLA block), which utilizes convolutions with different kernel sizes. Furthermore, to address the boundary uncertainty caused by patch division in the transformer, we introduce a novel global transformer block (GT block), which allows each patch to gather full-size feature information.Extensive experimental results on three publicly available skin datasets (PH2, ISIC-2017, and ISIC-2018) demonstrate that ETU-Net outperforms state-of-the-art hybrid methods based on CNN and Transformer in terms of segmentation performance. Moreover, ETU-Net exhibits excellent generalization ability in practical segmentation applications on dermatoscopy images contributed by the Wuxi No.2 People's Hospital.We propose ETU-Net, a novel multi-scale U-Net model guided by edge enhancement, which can address the challenges posed by complex lesion shapes and ambiguous boundaries in skin lesion segmentation tasks.