Daigo Yuki, Daigo Erina, Fukuoka Hiroshi, Fukuoka Nobuko, Idogaki Jun, Taniguchi Yusuke, Tsutsumi Takashi, Ishikawa Masatsugu, Takahashi Kazuya
Department of Geriatric Dentistry, Osaka Dental University, 2-2-14 Higashitanabe, Higashisumiyoshi-ku, Osaka 546-0032, Japan.
Nogami Dental Office, 4-22-18 Nishiimagawa, Higashisumiyoshi-ku, Osaka 546-0042, Japan.
Diseases. 2023 Nov 28;11(4):172. doi: 10.3390/diseases11040172.
A number of studies have recently demonstrated the effectiveness of CO laser irradiation for the repair and regeneration of scar tissue from injuries or surgical wounds. However, such studies of the oral mucosa are highly limited. Previous studies using CO laser irradiation have indicated that two factors contribute to esthetic healing, namely, artificial scabs, which are a coagulated and carbonized blood layer formed on the wound surface, and photobiomodulation therapy (PBMT) for suppressing wound scarring and promoting wound healing. This review outlines basic research and clinical studies of esthetic healing with the use of a CO laser for both artificial scab formation by high-intensity laser therapy and PBMT in the treatment of injuries and surgical wounds with small parenchymal defects in oral soft tissues. The results showed that the wound surface was covered by an artificial scab, enabling the accumulation of blood and the perfusion necessary for tissue regeneration and repair. Subsequent PBMT also downregulated the expression of transformation growth factor-b1, which is involved in tissue scarring, and decreased the appearance of myofibroblasts. Taken together, artificial scabs and PBMT using CO lasers contribute to the suppression of scarring in the tissue repair process, leading to favorable esthetic and functional outcomes of wound healing.
最近的一些研究表明，二氧化碳激光照射对损伤或手术伤口瘢痕组织的修复和再生具有有效性。然而，此类关于口腔黏膜的研究非常有限。以往使用二氧化碳激光照射的研究表明，有两个因素有助于实现美观愈合，即人工痂皮，它是在伤口表面形成的一层凝固碳化的血层，以及光生物调节疗法（PBMT），用于抑制伤口瘢痕形成并促进伤口愈合。本综述概述了利用二氧化碳激光进行美观愈合的基础研究和临床研究，该激光用于通过高强度激光疗法形成人工痂皮以及在治疗口腔软组织实质缺损较小的损伤和手术伤口时进行PBMT。结果显示，伤口表面被人工痂皮覆盖，从而能够积累血液以及组织再生和修复所需的灌注。随后的PBMT还下调了参与组织瘢痕形成的转化生长因子-β1的表达，并减少了肌成纤维细胞的出现。综上所述，使用二氧化碳激光形成的人工痂皮和PBMT有助于在组织修复过程中抑制瘢痕形成，从而实现伤口愈合良好的美观和功能效果。
