微量元素在心血管疾病中的作用。
The Role of Trace Elements in Cardiovascular Diseases.
作者信息
Wechselberger Christian, Messner Barbara, Bernhard David
机构信息
Division of Pathophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, Johannes Kepler University Linz, 4020 Linz, Austria.
Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, Austria.
出版信息
Toxics. 2023 Nov 23;11(12):956. doi: 10.3390/toxics11120956.
Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.
必需微量元素在人体生理过程中发挥着重要作用，并与调节细胞代谢的各种功能相关。另一方面，非必需微量元素往往具有充分记录的毒性，由于它们在环境中广泛存在且在生物体中积累，对疾病的发生和发展具有危险性。因此，非必需微量元素被视为严重的环境危害物，即使在低浓度下也对健康有害。这些元素的许多代表物在我们的环境中以污染物的形式存在，许多人在其一生中可能会接触到大量这些物质。最常见的非必需微量元素中包括重金属，它们也与人类急性中毒有关。当这些元素在多年的慢性暴露过程中在体内积累时，它们常常会对各种组织和器官造成严重的健康损害。在这篇综述文章中，将更详细地探讨选定的必需和非必需微量元素的作用及其在心血管系统典型病理生理过程发展中的作用。
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