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从一名健康男性供体的外周血单个核细胞中生成人诱导多能干细胞系（OGIi001）。

Generation of a human induced pluripotent stem cell line (OGIi001) from peripheral blood mononuclear cells of a healthy male donor.

机构信息

Ocular Genomics Institute, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, 02114, USA.

Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.

出版信息

Stem Cell Res. 2024 Feb;74:103280. doi: 10.1016/j.scr.2023.103280. Epub 2023 Dec 13.

DOI:10.1016/j.scr.2023.103280
PMID:38134577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11226232/
Abstract

We have successfully derived a novel human induced pluripotent stem cell (hiPSC) line using non-integrative Sendai virus. This hiPSC line was generated from a healthy male adult donor, aged 55, and subjected to thorough characterization and extensive quality control. The analysis confirmed the expression of undifferentiated stem cell markers, demonstrated the ability to differentiate into the three germ layers, and revealed the absence of any chromosomal abnormalities.

摘要

我们成功地使用非整合性的仙台病毒衍生出了一种新型的人类诱导多能干细胞（hiPSC）系。该 hiPSC 系来源于一位健康的 55 岁男性成年供体，并经过了全面的特征描述和广泛的质量控制。分析确认了未分化干细胞标志物的表达，证明了其向三个胚层分化的能力，并显示出没有任何染色体异常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/11226232/5d6fd8747f25/nihms-2002025-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/11226232/5d0103a00806/nihms-2002025-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/11226232/5d6fd8747f25/nihms-2002025-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/11226232/5d0103a00806/nihms-2002025-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/11226232/5d6fd8747f25/nihms-2002025-f0002.jpg

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Stem Cells. 2013 May;31(5):966-78. doi: 10.1002/stem.1339.