诱导多能干细胞系（KNIHi001-A）的建立，方法是对一位帕金森病患者外周血单个核细胞进行重编程。
Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease.
机构信息
Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea.
nSAGE Inc., Incheon, Republic of Korea.
出版信息
Stem Cell Res. 2024 Apr;76:103358. doi: 10.1016/j.scr.2024.103358. Epub 2024 Feb 23.
Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.
帕金森病是一种退行性脑疾病，其特征是多巴胺神经元退化和多巴胺转运体丧失。在这项研究中，我们从一位 76 岁帕金森病男性的外周血单核细胞（PBMCs）中生成了一个诱导多能干细胞（iPSC）系，KNIHi001-A。非整合性仙台病毒被用于重编程 iPSC。iPSC 表现出多能性标志物、正常核型、病毒清除和分化为三个胚层的能力。
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