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通过超短激光结构化改进用于活性骨替代物的金属掺杂β-磷酸三钙支架

Improvement of Metal-Doped β-TCP Scaffolds for Active Bone Substitutes via Ultra-Short Laser Structuring.

作者信息

Soares Íris, Sotelo Lamborghini, Erceg Ina, Jean Florian, Lasgorceix Marie, Leriche Anne, Sikirić Maja Dutour, Marušić Katarina, Christiansen Silke, Daskalova Albena

机构信息

Laboratory of Micro and Nano-Photonics, Institute of Electronics, Bulgarian Academy of Sciences, 72 Tsarigradsko Chaussee Blvd, 1784 Sofia, Bulgaria.

Institute for Nanotechnology and Correlative Microscopy vV INAM, Äußere Nürnberger Str. 62, 91301 Forcheim, Germany.

出版信息

Bioengineering (Basel). 2023 Dec 6;10(12):1392. doi: 10.3390/bioengineering10121392.

Abstract

Various efforts have been made to develop antibacterial biomaterials capable of also sustaining bone remodulation to be used as bone substitutes and reduce patient infection rates and related costs. In this work, beta-tricalcium phosphate (β-TCP) was chosen due to its known biocompatibility and use as a bone substitute. Metal dopants were incorporated into the crystal structure of the β-TCP, and disks were produced from this material. Magnesium and strontium, as well as copper and silver, were chosen as dopants to improve the osteogenic and antibacterial properties, respectively. The surface of the β-TCP samples was further modified using a femtosecond laser system. Grid and line patterns were produced on the plates' surface via laser ablation, creating grooves with depths lower than 20 μm and widths between 20 and 40 μm. Raman and FTIR analysis confirmed that laser ablation did not result in the degradation or phase change of the materials, making it suitable for surface patterning. Laser ablation resulted in increased hydrophilicity of the materials, as the control samples (non-ablated samples) have WCA values ranging from 70° to 93° and become, upon laser ablation, superwicking surfaces. Confocal measurements show an increase in specific surface area of 50% to 200% compared to the control. Overall, the results indicate the potential of laser ablation to improve the surface characteristics of β-TCP, which may lead to an improvement in the antibacterial and osteogenic properties of the produced materials.

摘要

人们已经做出了各种努力来开发能够维持骨重塑的抗菌生物材料,用作骨替代物,以降低患者感染率和相关成本。在这项工作中,选择β-磷酸三钙(β-TCP)是因为其已知的生物相容性以及作为骨替代物的用途。将金属掺杂剂掺入β-TCP的晶体结构中,并用这种材料制成圆盘。分别选择镁和锶以及铜和银作为掺杂剂,以改善成骨性能和抗菌性能。使用飞秒激光系统对β-TCP样品的表面进行进一步改性。通过激光烧蚀在板表面产生网格和线条图案,形成深度小于20μm且宽度在20至40μm之间的凹槽。拉曼光谱和傅里叶变换红外光谱分析证实,激光烧蚀不会导致材料降解或相变,使其适用于表面图案化。激光烧蚀导致材料亲水性增加,因为对照样品(未烧蚀样品)的水接触角值在70°至93°之间,而在激光烧蚀后变成超疏水表面。共聚焦测量表明,与对照相比,比表面积增加了50%至200%。总体而言,结果表明激光烧蚀具有改善β-TCP表面特性的潜力,这可能会导致所制备材料的抗菌和成骨性能得到改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d8d/10741177/5fe1c5250898/bioengineering-10-01392-g001.jpg

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