Thronicke Anja, Oei Shiao Li, Grieb Gerrit, Grabowski Patricia, Roos Juliane, Schad Friedemann
Research Institute Havelhöhe gGmbH, Hospital Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany.
Department of Plastic Surgery and Hand Surgery, Hospital Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany.
Cancers (Basel). 2023 Dec 8;15(24):5763. doi: 10.3390/cancers15245763.
Baseline quality of life (bQL) has been shown to be a predictor of the clinical outcome of oncological patients. The primary objective of the present study was to examine the role of bQL as a treatment predictor in oncological patients.
In this prospective study, all-stage cancer patients registered in the Network Oncology registry were enrolled, and their bQL at diagnosis was evaluated.
Five hundred and thirty-eight oncological patients were eligible (median age 64 years). We show that survival-predicting bQL variables such as pain, low physical functioning or financial burden at tumor diagnosis were linked to lower systemic treatment ( = 0.03), reduced surgery ( = 0.007) or reduced oncological treatment compliance (0.01), respectively. Lastly, female gender and older cancer patients exhibited a tempered bQL.
Our study is one of the first to reveal that bQL at tumor diagnosis is significantly associated with the prediction of oncological treatment with distinctive age- and gender-related patterns. Our results emphasize the need to address the physical, psychosocial, and financial burden of cancer patients prior to their oncological treatment with respect to age and gender. The associations found here pave the way for early integration of patient-reported outcomes into oncological supportive concepts.
基线生活质量（bQL）已被证明是肿瘤患者临床结局的一个预测指标。本研究的主要目的是探讨bQL作为肿瘤患者治疗预测指标的作用。
在这项前瞻性研究中，纳入了在网络肿瘤登记处登记的所有阶段癌症患者，并评估了他们诊断时的bQL。
538例肿瘤患者符合条件（中位年龄64岁）。我们发现，肿瘤诊断时预测生存的bQL变量，如疼痛、身体功能低下或经济负担，分别与较低的全身治疗（P = 0.03）、较少的手术（P = 0.007）或较低的肿瘤治疗依从性（P = 0.01）相关。最后，女性和老年癌症患者的bQL较低。
我们的研究是首批揭示肿瘤诊断时的bQL与具有独特年龄和性别相关模式的肿瘤治疗预测显著相关的研究之一。我们的结果强调，在肿瘤治疗之前，需要针对年龄和性别解决癌症患者的身体、心理社会和经济负担。此处发现的关联为将患者报告的结局早期纳入肿瘤支持性概念铺平了道路。
